liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Collagenase treatment of Dupuytrens contracture using a modified injection method
Department Orthoped, Sweden; Ystad Hospital, Sweden; Lund University, Sweden.
Department Orthoped, Sweden; Ystad Hospital, Sweden; Lund University, Sweden.
Department Orthoped, Sweden; Ystad Hospital, Sweden.
Department Orthoped, Sweden; Ystad Hospital, Sweden.
Visa övriga samt affilieringar
2015 (Engelska)Ingår i: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 86, nr 3, s. 310-315Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background and purpose - Treatment of Dupuytrens contracture (DC) with collagenase Clostridium histolyticum (CCH) consists of injection followed by finger manipulation. We used a modified method, injecting a higher dose than recommended on the label into several parts of the cord, which allows treatment of multiple joint contractures in 1 session and may increase efficacy. We studied the occurrence of skin tears and short-term outcome with this procedure. Patients and methods - We studied 164 consecutive hands with DC, palpable cord, and extension deficit of greater than= 20 degrees in the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joint (mean patient age 70 years, 82% men). A hand surgeon injected all the content of 1 CCH vial (approximately 0.80 mg) into multiple spots in the cord and performed finger extension under local anesthesia after 1 or 2 days. A nurse recorded skin tears on a diagram and conducted a standard telephone follow-up within 4 weeks. A hand therapist measured joint contracture before injection and at a median of 23 (IQR: 7-34) days after finger extension. Results - A skin tear occurred in 66 hands (40%). The largest diameter of the tear was less than= 5 mm in 30 hands and greater than 10 mm in 14 hands. Hands with skin tear had greater mean pretreatment MCP extension deficit than those without tear: 59 degrees (SD 26) as opposed to 32 degrees (SD 23). Skin tear occurred in 21 of 24 hands with MCP contracture of greater than= 75 degrees. All tears healed with open-wound treatment. No infections occurred. Mean improvement in total (MCP + PIP) extension deficit was 55 degrees (SD 28). Interpretation - Skin tears occurred in 40% of hands treated with collagenase injections, but only a fifth of them were larger than 1 cm. Tears were more likely in hands with severe MCP joint contracture. All tears healed without complications. Short-term contracture reduction was good.

Ort, förlag, år, upplaga, sidor
Informa Healthcare: Creative Commons Attribution Non-Commercial / Informa Healthcare , 2015. Vol. 86, nr 3, s. 310-315
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-120056DOI: 10.3109/17453674.2015.1019782ISI: 000355976700008PubMedID: 25695745OAI: oai:DiVA.org:liu-120056DiVA, id: diva2:839978
Anmärkning

Funding Agencies|Hassleholm Hospital

Tillgänglig från: 2015-07-06 Skapad: 2015-07-06 Senast uppdaterad: 2017-12-04

Open Access i DiVA

fulltext(616 kB)402 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 616 kBChecksumma SHA-512
a73de367a5e5289834800fee0b5f358a8c970c179394ec1421f5238174af261f47ce77163fc0fdddba85fe956bc1c8d6a331035b9b4ce6c4e6c9e300b5387d5d
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Person

Waldén, Markus

Sök vidare i DiVA

Av författaren/redaktören
Waldén, Markus
Av organisationen
Avdelningen för samhällsmedicinMedicinska fakulteten
I samma tidskrift
Acta Orthopaedica
Klinisk medicin

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 402 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 243 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf