liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The value of individual measurements for tumor control probability predictions in head and neck patients
Stockholm University, Sweden.ORCID-id: 0000-0002-7101-240X
Karolinska University Hospital, Sweden.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.ORCID-id: 0000-0001-8171-2541
2015 (Engelska)Ingår i: World Congress on Medical Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada / [ed] Jaffray David A., Springer, 2015, Vol. 51, s. 1675-1678Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

In the age of personalized cancer medicine, individual measurements of in vitro radiosensitivity and proliferation parameters have great potential for predicting treatment outcome. However, cellular radiosensitivity is quite heterogeneous and therefore concerns exist towards its impact on treatment predictions. It was therefore the purpose of this study to investigate this aspect. Individually-determined radiosensitivities and potential doubling times, as well as tumor volumes from 46 head-and-neck carcinomas treated with radiotherapy, were used to predict tumor control probabilities (TCP) under various biologically-relevant assumptions for heterogeneity in radiosensitivity. TCP predictions were then compared to clinical local control using a ROC curve analysis. The analysis showed that TCP calculated under the assumption of heterogeneous radiosensitivity have the same power of distinguishing between patients with or without local control as from single values for the radiobiological parameters (a sensitivity of 66% and a specificity of 80% for an area under the curve of 0.69). The only difference was in the discrimination criterion (TCP>93% for single parameters and TCP>65% for heterogeneous parameters), illustrating the difference in appearance of the TCP curve under the assumption of heterogeneity. Nevertheless, the results showed that individually determined radiobiological parameters could be quite effective towards predicting treatment outcome for individual patients.

Ort, förlag, år, upplaga, sidor
Springer, 2015. Vol. 51, s. 1675-1678
Serie
IFMBE Proceedings, ISSN 1680-0737
Nyckelord [en]
radiosensitivity, potential doubling time, head-and-neck carcinomas, TCP
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:liu:diva-120263DOI: 10.1007/978-3-319-19387-8_407ISI: 000381813000407ISBN: 978-3-319-19387-8 (tryckt)ISBN: 978-3-319-19386-1 (tryckt)OAI: oai:DiVA.org:liu-120263DiVA, id: diva2:842839
Konferens
World Congress on Medical Physics and Biomedical Engineering
Tillgänglig från: 2015-07-22 Skapad: 2015-07-22 Senast uppdaterad: 2017-12-18

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Person

Toma-Dasu, IulianaDasu, Alexandru

Sök vidare i DiVA

Av författaren/redaktören
Toma-Dasu, IulianaDasu, Alexandru
Av organisationen
Avdelningen för radiologiska vetenskaperMedicinska fakultetenRadiofysikavdelningen US
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetricpoäng

doi
isbn
urn-nbn
Totalt: 129 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf