liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Reduction in resource use with the misoprostol vaginal insert vs the dinoprostone vaginal insert for labour induction: a model-based analysis from a United Kingdom healthcare perspective
Spire Bristol Hospital, England.
Spire Bristol Hospital, England.
Covance Inc, England.
Covance Inc, England.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 16, nr 1, s. 49-Artikel i tidskrift (Refereegranskat) Published
Resurstyp
Text
Abstract [en]

Background: In view of the increasing pressure on the UKs maternity units, new methods of labour induction are required to alleviate the burden on the National Health Service, while maintaining the quality of care for women during delivery. A model was developed to evaluate the resource use associated with misoprostol vaginal inserts (MVIs) and dinoprostone vaginal inserts (DVIs) for the induction of labour at term. Methods: The one-year Markov model estimated clinical outcomes in a hypothetical cohort of 1397 pregnant women (parous and nulliparous) induced with either MVI or DVI at Southmead Hospital, Bristol, UK. Efficacy and safety data were based on published and unpublished results from a phase III, double-blind, multicentre, randomised controlled trial. Resource use was modelled using data from labour induction during antenatal admission to patient discharge from Southmead Hospital. The models sensitivity to key parameters was explored in deterministic multi-way and scenario-based analyses. Results: Over one year, the model results indicated MVI use could lead to a reduction of 10,201 h (28.9 %) in the time to vaginal delivery, and an increase of 121 % and 52 % in the proportion of women achieving vaginal delivery at 12 and 24 h, respectively, compared with DVI use. Inducing women with the MVI could lead to a 25.2 % reduction in the number of midwife shifts spent managing labour induction and 451 fewer hospital bed days. These resource utilisation reductions may equate to a potential 27.4 % increase in birthing capacity at Southmead Hospital, when using the MVI instead of the DVI. Conclusions: Resource use, in addition to clinical considerations, should be considered when making decisions about labour induction methods. Our model analysis suggests the MVI is an effective method for labour induction, and could lead to a considerable reduction in resource use compared with the DVI, thereby alleviating the increasing burden of labour induction in UK hospitals.

Ort, förlag, år, upplaga, sidor
BIOMED CENTRAL LTD , 2016. Vol. 16, nr 1, s. 49-
Nyckelord [en]
Misoprostol; Dinoprostone; Labour induction; Resource; Vaginal insert
Nationell ämneskategori
Reproduktionsmedicin och gynekologi Övrig annan medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-125807DOI: 10.1186/s12913-016-1278-9ISI: 000369968100002PubMedID: 26864022OAI: oai:DiVA.org:liu-125807DiVA, id: diva2:910322
Anmärkning

Funding Agencies|Ferring Pharmaceuticals A/S

Tillgänglig från: 2016-03-08 Skapad: 2016-03-04 Senast uppdaterad: 2018-03-22

Open Access i DiVA

fulltext(1140 kB)163 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1140 kBChecksumma SHA-512
c4d20b4469f3fca1172bd627ceab74a264147079a3cb21fd4652fc91d178f87f03793b363ece51820363fa053b82f424c56ff31fb9e319a50a9ff7ad6eebe9eb
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed
Av organisationen
Linköpings universitet
I samma tidskrift
BMC Health Services Research
Reproduktionsmedicin och gynekologiÖvrig annan medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 163 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 434 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf