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Post-mortem 1.5T MR quantification of regular anatomical brain structures
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Institute of Forensic Medicine, University of Bern, Switzerland.
Institute of Forensic Medicine, University of Bern, Bern, Switzerland.
Institute of Forensic Medicine, University of Bern, Bern, Switzerland.
Institute of Forensic Medicine, University of Bern, Bern, Switzerland; Department of Diagnostic, Interventional and Pediatric Radiology, University of Bern, Inselspital, Bern, Switzerland.
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2016 (Engelska)Ingår i: International journal of legal medicine (Print), ISSN 0937-9827, E-ISSN 1437-1596, Vol. 130, nr 4, s. 1071-1080Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

Recently, post-mortem MR quantification has been introduced to the field of post-mortem magnetic resonance imaging. By usage of a particular MR quantification sequence, T1 and T2 relaxation times and proton density (PD) of tissues and organs can be quantified simultaneously. The aim of the present basic research study was to assess the quantitative T1, T2, and PD values of regular anatomical brain structures for a 1.5T application and to correlate the assessed values with corpse temperatures. In a prospective study, 30 forensic cases were MR-scanned with a quantification sequence prior to autopsy. Body temperature was assessed during MR scans. In synthetically calculated T1, T2, and PD-weighted images, quantitative T1, T2 (both in ms) and PD (in %) values of anatomical structures of cerebrum (Group 1: frontal gray matter, frontal white matter, thalamus, internal capsule, caudate nucleus, putamen, and globus pallidus) and brainstem/cerebellum (Group 2: cerebral crus, substantia nigra, red nucleus, pons, cerebellar hemisphere, and superior cerebellar peduncle) were assessed. The investigated brain structures of cerebrum and brainstem/cerebellum could be characterized and differentiated based on a combination of their quantitative T1, T2, and PD values. MANOVA testing verified significant differences between the investigated anatomical brain structures among each other in Group 1 and Group 2 based on their quantitative values. Temperature dependence was observed mainly for T1 values, which were slightly increasing with rising temperature in the investigated brain structures in both groups. The results provide a base for future computer-aided diagnosis of brain pathologies and lesions in post-mortem magnetic resonance imaging.

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Springer, 2016. Vol. 130, nr 4, s. 1071-1080
Nyckelord [en]
Brain, MR quantification, Post-mortem magnetic resonance imaging (PMMR), Forensic, Neuroimaging
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
URN: urn:nbn:se:liu:diva-130269DOI: 10.1007/s00414-016-1318-3ISI: 000378817900026PubMedID: 26872469OAI: oai:DiVA.org:liu-130269DiVA, id: diva2:950630
Tillgänglig från: 2016-08-01 Skapad: 2016-07-28 Senast uppdaterad: 2018-01-10Bibliografiskt granskad

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Zech, Wolf-DieterPersson, AndersWarntjes, Marcel Jan Bertus

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Zech, Wolf-DieterPersson, AndersWarntjes, Marcel Jan Bertus
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Avdelningen för radiologiska vetenskaperMedicinska fakultetenRöntgenkliniken i LinköpingCentrum för medicinsk bildvetenskap och visualisering, CMIVAvdelningen för kardiovaskulär medicinFysiologiska kliniken US
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International journal of legal medicine (Print)
Farmakologi och toxikologi

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