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Inter-hemispheric plasticity in patients with median nerve injury
Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Norrköping. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Region Östergötland, Sinnescentrum, Anestesi- och intensivvårdskliniken VIN.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Region Östergötland, Sinnescentrum, Hand- och plastikkirurgiska kliniken US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Medicinska fakulteten.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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2016 (Engelska)Ingår i: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 628, s. 59-66Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Peripheral nerve injuries result in reorganization within the contralateral hemisphere. Furthermore, recent animal and human studies have suggested that the plastic changes in response to peripheral nerve injury also include several areas of the ipsilateral hemisphere. The objective of this study was to map the inter-hemispheric plasticity in response to median nerve injury, to investigate normal differences in contra- and ipsilateral activation, and to study the impact of event-related or blocked functional magnetic resonance imaging (fMRI) design on ipsilateral activation. Four patients with median nerve injury at the wrist (injured and epineurally sutured amp;gt;2 years earlier) and ten healthy volunteers were included. 3T fMRI was used to map the hemodynamic response to brain activity during tactile stimulation of the fingers, and a laterality index (LI) was calculated. Stimulation of Digits II-III of the injured hand resulted in a reduction in contralateral activation in the somatosensory area SI. Patients had a lower LI (0.21 +/- 0.15) compared to healthy controls (0.60 +/- 0.26) indicating greater ipsilateral activation of the primary somatosensory cortex. The spatial dispersion of the coordinates for areas SI and SII was larger in the ipsilateral than in the contralateral hemisphere in the healthy controls, and was increased in the contralateral hemisphere of the patients compared to the healthy controls. There was no difference in LI between the event-related and blocked paradigms. In conclusion, patients with median nerve injury have increased ipsilateral SI area activation, and spatially more dispersed contralateral SI activation during tactile stimulation of their injured hand. In normal subjects ipsilateral activation has larger spatial distribution than the contralateral. Previous findings in patients performed with the blocked fMRI paradigm were confirmed. The increase in ipsilateral SI activation may be due to an interhemispheric disinhibition associated with changes in the afferent signal inflow to the contralateral primary somatosensory cortex.

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Elsevier, 2016. Vol. 628, s. 59-66
Nyckelord [en]
Peripheral nerve injury; Regeneration; Cortical plasticity; fMRI; Median nerve; Human
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:liu:diva-131686DOI: 10.1016/j.neulet.2016.06.018ISI: 000381590800010PubMedID: 27291455OAI: oai:DiVA.org:liu-131686DiVA, id: diva2:1014861
Tillgänglig från: 2016-10-03 Skapad: 2016-09-30 Senast uppdaterad: 2017-05-02Bibliografiskt granskad

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Nyman, TorbjörnHansson, ThomasEngström, Maria
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Ortopedkliniken i NorrköpingAnestesi- och intensivvårdskliniken VINAvdelningen för kliniska vetenskaperHand- och plastikkirurgiska kliniken USCentrum för medicinsk bildvetenskap och visualisering, CMIVMedicinska fakultetenAvdelningen för radiologiska vetenskaper
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Neuroscience Letters
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