liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Arginine and Caries Prevention: A Systematic Review
Karolinska Institute, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för hälso- och sjukvårdsanalys. Linköpings universitet, Medicinska fakulteten.
Swedish Agency Health Technology Assessment and Assessment, Sweden.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 50, nr 4, s. 383-393Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Objectives: To evaluate the available evidence that the use of arginine-containing dental care products prevents the development of new caries lesions and the progression of existing lesions. Search Methods: We performed a systematic literature search of databases including PubMed, the Cochrane Library and EMBASE. Selection Criteria: We selected randomized controlled trials of treatment with arginine in fluoride-containing dental products measuring dental caries incidence or progression in children, adults and elderly subjects. Data Collection and Analysis: Two review authors independently assessed trials for risk of bias and evaluated overall study quality using the GRADE classification. Main Results: Due to conflicts of interest and weak transferability to Swedish conditions, no conclusions can be drawn from studies on the effects of arginine-fluoride toothpaste in children. Arginine-containing toothpaste costs about 40% more than basic fluoride toothpaste; to determine whether it is more cost-effective, the higher cost must be considered in relation to any additional caries-preventive effect. The literature review also disclosed some questionable research ethics: in several of the studies, the children in the control group used non-fluoride toothpaste. Toothpaste without fluoride is not as effective against dental caries as the standard treatment - fluoride toothpaste - which has a well -documented effect. This contravenes the fundamental principles of research ethics. Conclusion: At present there is insufficient evidence in support of a caries-preventive effect for the inclusion of arginine in toothpastes. More rigorous studies, and studies which are less dependent on commercial interests, are required. (C) 2016 S. Karger AG, Basel

Ort, förlag, år, upplaga, sidor
KARGER , 2016. Vol. 50, nr 4, s. 383-393
Nyckelord [en]
Arginine; Arginine-fluoride toothpaste; Caries; Caries prevention; Dental care
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:liu:diva-131917DOI: 10.1159/000446249ISI: 000383216000005PubMedID: 27403876OAI: oai:DiVA.org:liu-131917DiVA, id: diva2:1034815
Tillgänglig från: 2016-10-13 Skapad: 2016-10-11 Senast uppdaterad: 2017-11-29

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Davidson, Thomas
Av organisationen
Avdelningen för hälso- och sjukvårdsanalysMedicinska fakulteten
I samma tidskrift
Caries Research
Odontologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 114 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf