liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology
Heidelberg University, Germany.
Heidelberg University, Germany.
Heidelberg University, Germany.
Heidelberg University, Germany.
Vise andre og tillknytning
2016 (engelsk)Inngår i: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 6, nr e861Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

It has been proposed that vulnerability to nicotine addiction is moderated by variation at the mu-opioid receptor locus (OPRM1), but results from human studies vary and prospective studies based on genotype are lacking. We have developed a humanized mouse model of the most common functional OPRM1 polymorphism rs1799971_A4G (A118G). Here we use this model system together with a cohort of German youth to examine the role of the OPRM1 A118G variation on nicotine reward. Nicotine reinforcement was examined in the humanized mouse model using i.v. self-administration. Male (n = 17) and female (n = 26) mice homozygous either for the major human A allele (AA) or the minor G allele (GG) underwent eight daily 2 h sessions of nicotine self-administration. Furthermore, male (n = 104) and female (n = 118) subjects homozygous for the A allele or carrying the G allele from the Mannheim Study of Children at Risk were evaluated for pleasurable and unpleasant experiences during their initial smoking experience. A significant sex-by-genotype effect was observed for nicotine self-administration. Male 118GG mice demonstrated higher nicotine intake than male 118AA mice, suggesting increased nicotine reinforcement. In contrast, there was no genotype effect in female mice. Human male G allele carriers reported increased pleasurable effects from their first smoking experience, as compared to male homozygous A, female G and female homozygous A allele carriers. The 118G allele appears to confer greater sensitivity to nicotine reinforcement in males, but not females.

sted, utgiver, år, opplag, sider
NATURE PUBLISHING GROUP , 2016. Vol. 6, nr e861
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-132082DOI: 10.1038/tp.2016.132ISI: 000383420800003PubMedID: 27459726OAI: oai:DiVA.org:liu-132082DiVA, id: diva2:1038382
Merknad

Funding Agencies|Bundesministerium fur Bildung und Forschung (BMBF) [FKZ 01EW1112, 01ZX1311A]; Deutsche Forschungsgemeinschaft (DFG) [SPP1226, SP 383/4-1]; DFG

Tilgjengelig fra: 2016-10-18 Laget: 2016-10-17 Sist oppdatert: 2018-01-14

Open Access i DiVA

fulltext(528 kB)117 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 528 kBChecksum SHA-512
4e2c2650b29666bc2331cb459d26d4ab71dd695c4a9fc019851dce2257504c6fa4c488cd9cf61b182e65780ecf3390b7b7303e47db3a0d546e89810202d5150d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Heilig, Markus
Av organisasjonen
I samme tidsskrift
Translational Psychiatry

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 117 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 338 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf