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Melatonin receptors MT1 and MT2 are expressed in spermatozoa from several seasonal and nonseasonal breeder species
University of Zaragoza, Spain.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.ORCID-id: 0000-0002-0256-1958
University of Leon, Spain.
University of Leon, Spain.
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2016 (Engelska)Ingår i: Theriogenology, ISSN 0093-691X, E-ISSN 1879-3231, Vol. 86, nr 8, s. 1958-1968Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Melatonin is a ubiquitous and multipurpose molecule, and one of its roles is to regulate reproduction in some seasonal mammals. Our group has previously reported the variation in the melatonin levels in ram seminal plasma along the year and identified MT1 and MT2 receptors in ram spermatozoa. The objective of this study was to elucidate whether the presence of melatonin receptors (MT1 and MT2) in the sperm plasma membrane, and melatonin in the seminal plasma is related to seasonal breeding. For this purpose, the presence of melatonin receptors and tseasonal breeder (epididymal spermatozoa); bull as a conventional nonseasonhe levels of melatonin in seminal plasma have been examined in several species: donkey and stallion as long-day breeders; red deer as a wild, short-day, highly al breeder; boar as a seasonal breeder, under management techniques; and dog as possible a seasonal breeder not regulated by melatonin. We have detected measurable levels of melatonin in the seminal plasma of all ejaculated semen samples (from donkey, stallion, boar, bull, and dog). Also, and for the first time, we have demonstrated the presence of MT1 and MT2 melatonin receptors in the spermatozoa of all these species, regardless their type of reproduction or sperm source (ejaculated or epididymal), using indirect immunofluorescence techniques and Western blotting. Our findings suggest that melatonin and melatonin receptors may be universally distributed in the reproductive system of mammals and that the sperm melatonin receptors cells may not be necessarily related with seasonal reproduction. Furthermore, the presence of MT1 at the cytoplasmic droplet in immature ejaculated stallion spermatozoa found in one sample and epididymal red deer spermatozoa suggests that melatonin may be involved in specific functions during spermatogenesis and sperm maturation, like protecting spermatozoa from oxidative damage, this activity being mediated through these receptors. (C) 2016 Elsevier Inc. All rights reserved.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE INC , 2016. Vol. 86, nr 8, s. 1958-1968
Nyckelord [en]
Donkey; Stallion; Boar; Bull; Deer; Dog
Nationell ämneskategori
Reproduktionsmedicin och gynekologi
Identifikatorer
URN: urn:nbn:se:liu:diva-132331DOI: 10.1016/j.theriogenology.2016.06.016ISI: 000384628200013PubMedID: 27448693OAI: oai:DiVA.org:liu-132331DiVA, id: diva2:1046211
Anmärkning

Funding Agencies| [CICYT-AGL2013-43328-P]; [CICYT-AGL2012-39903]; [GV-BFI-2010-229]; [DGA A-26]

Tillgänglig från: 2016-11-12 Skapad: 2016-11-01 Senast uppdaterad: 2017-11-29

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Vicente Carrillo, Alejandro
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Avdelningen för kliniska vetenskaperMedicinska fakulteten
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Theriogenology
Reproduktionsmedicin och gynekologi

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