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Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Hudkliniken i Östergötland. (Ingrid Asp Psoriasis Research Center)
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Hudkliniken i Östergötland. (Ingrid Asp Psoriasis Research Center)
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. (Ingrid Asp Psoriasis Research Center)
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Hudkliniken i Östergötland. (Ingrid Asp Psoriasis Research Center)
2017 (engelsk)Inngår i: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, nr 4, s. 441-448Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Psoriasin, which is highly expressed in psoriasis, is encoded by a gene located within the epidermal differentiation complex. The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. Immunohistochemical staining revealed a gradient of psoriasin expression in the psoriatic epidermis with highest expression in the suprabasal, differentiated layers. Induction of keratinocyte differentiation caused concurrent expression of psoriasin and the differentiation marker involucrin. The differentiation-induced psoriasin expression was found to be mediated by the protein kinase C pathway. The downregulation of psoriasin expression by small interfering RNA revealed that psoriasin mediates the expression of involucrin, desmoglein 1, transglutaminase 1 and CD24 in normal differentiation. The lentivirus-mediated overexpression of psoriasin, mimicking the psoriatic milieu, gave rise to an altered regulation of differentiation genes and an expression pattern reminiscent of that in psoriatic epidermis. These findings suggest that psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis.

sted, utgiver, år, opplag, sider
Society for the Publication of Acta Dermato - Venereologica , 2017. Vol. 97, nr 4, s. 441-448
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URN: urn:nbn:se:liu:diva-133860DOI: 10.2340/00015555-2596ISI: 000401127000005PubMedID: 27958610OAI: oai:DiVA.org:liu-133860DiVA, id: diva2:1064659
Merknad

Funding agencies: Ingrid Asp Foundation; Welander Foundation; Swedish psoriasis association; Medical Research Council

Tilgjengelig fra: 2017-01-12 Laget: 2017-01-12 Sist oppdatert: 2018-05-02bibliografisk kontrollert

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