liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways: Relevance to the Pathogenesis of Alzheimers Disease
Banaras Hindu University, Division of Geriatrics, Department of Medicine, Banaras, India.
ICARE Institute of Medical Sciences and Research — Biochemistry, Haldia, India.
Institute of post Graduate Medical Education and Research, — Biochemistry, Kolkata, India.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Current Alzheimer Research, ISSN 1567-2050, E-ISSN 1875-5828, Vol. 13, nr 11, s. 1232-1248Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

The metabolic turnover of sphingolipids produces several signaling molecules that profoundly affect the proliferation, differentiation and death of cells. In particular, an enormous body of information is available that defines the varied role of ceramide and sphingosine-1-phosphate in cell death and survival. This review specifically examines the role of ceramide and sphingosine-1-phosphate in triggering neuronal death in Alzheimers disease by analyzing the data from post-mortem studies and experimental research. There is compelling evidence that ceramide plays a key role in the neurodegeneration and amyloidogenesis occurring in the brain in Alzheimers disease. Further, it appears that ceramide and amyloid beta protein orchestrate an attack on mitochondria to set in the pathways of cell death. However, the complexity of metabolic and signaling pathways of sphingolipid derivatives precludes an immediate identification of effective drug targets for the therapy of Alzheimers disease.

Ort, förlag, år, upplaga, sidor
BENTHAM SCIENCE PUBL LTD , 2016. Vol. 13, nr 11, s. 1232-1248
Nyckelord [en]
Sphingomyelin; Ceramide; Sphingosine-1-phosphate; Mitochondria; Amyloid beta protein; Apoptosis; Necroptosis; Alzheimers disease
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:liu:diva-133902DOI: 10.2174/1567205013666160603004239ISI: 000390335400004OAI: oai:DiVA.org:liu-133902DiVA, id: diva2:1064986
Tillgänglig från: 2017-01-13 Skapad: 2017-01-13 Senast uppdaterad: 2018-01-13

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Sök vidare i DiVA

Av författaren/redaktören
Sinha, Maitrayee Sardar
Av organisationen
Avdelningen för neuro- och inflammationsvetenskapMedicinska fakulteten
I samma tidskrift
Current Alzheimer Research
Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 62 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf