liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts
Fibrosis and Lung Injury DPU, England.
Fibrosis and Lung Injury DPU, England.
University of Manchester, England.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Ryhov Hospital, Sweden.ORCID iD: 0000-0002-2045-7142
Show others and affiliations
2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, no 1, p. 10-16Article in journal (Refereed) Published
Abstract [en]

The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentially expressed genes (20% change, p amp;lt; 0.05) obtained from microarray datasets derived from whole keloid biopsies and ex vivo-cultured keloid fibroblasts, both from distinct regions of the keloid lesion (leading edge, centre, and top) have been analysed to show that the TGF beta family plays a significant but spatially dependent role in regulation of keloid gene expression. Furthermore, we have identified additional upstream signalling molecules involved in driving keloid biology and provide information on therapeutic targets whose modulation might be expected to lead to significant therapeutic efficacy.

Place, publisher, year, edition, pages
ACTA DERMATO-VENEREOLOGICA , 2017. Vol. 97, no 1, p. 10-16
Keywords [en]
keloid disease; gene expression; microarray; TGF beta 1; upstream regulator
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-136356DOI: 10.2340/00015555-2462ISI: 000393894700004PubMedID: 27175945OAI: oai:DiVA.org:liu-136356DiVA, id: diva2:1087866
Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2023-12-28

Open Access in DiVA

fulltext(1288 kB)244 downloads
File information
File name FULLTEXT01.pdfFile size 1288 kBChecksum SHA-512
0111108b67d38abfc6bc4399092a0f13d9247262e91cb8f663f1b855304b4e8c3e229fbae5625d206ecd62eafbd64f38a58a268638d3620b4427a94111ae3cc4
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Seifert, Oliver
By organisation
Division of Cell BiologyFaculty of Medicine and Health Sciences
In the same journal
Acta Dermato-Venereologica
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 244 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 245 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf