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Colloid electrochemistry of conducting polymer: towards potential-induced in-situ drug release
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. Prince Songkla University, Thailand.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-8478-4663
Linköping University, Faculty of Science & Engineering. Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Stanford University, CA 94305 USA.
Prince Songkla University, Thailand.
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2017 (English)In: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 228, p. 407-412Article in journal (Refereed) Published
Abstract [en]

Over the past decades, controlled drug delivery system remains as one of the most important area in medicine for various diseases. We have developed a new electrochemically controlled drug release system by combining colloid electrochemistry and electro-responsive microcapsules. The pulsed electrode potential modulation led to the appearance of two processes available for the time-resolved registration in colloid microenvironment: change of the electronic charge of microparticles (from 0.5 ms to 0.1 s) followed by the drug release associated with ionic equilibration (1-10 s). The dynamic electrochemical measurements allow the distinction of drug release associated With ionic relaxation and the change of electronic charge of conducting polymer colloid microparticles. The amount of released drug (methylene blue) could be controlled by modulating the applied potential. Our study demonstrated a surface-potential driven controlled drug release of dispersion of conducting polymer carrier at the electrode interfaces, while the bulk colloids dispersion away from the electrode remains as a reservoir to improve the efficiency of localized drug release. The developed new methodology creates a model platform for the investigations of surface potential-induced in-situ electrochemical drug release mechanism. (C) 2017 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 228, p. 407-412
Keywords [en]
colloid electrochemistry; conducting polymer; potential-modulation; microcapsules; controlled drug release
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URN: urn:nbn:se:liu:diva-136666DOI: 10.1016/j.electacta.2017.01.028ISI: 000395211600047OAI: oai:DiVA.org:liu-136666DiVA, id: diva2:1089752
Note

Funding Agencies|Royal Golden Jubilee Ph.D-program (RGJ) - Thailand Research Fund [3.C.PS/51/B.1]

Available from: 2017-04-20 Created: 2017-04-20 Last updated: 2018-03-27

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