liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry
Skåne University Hospital, Sweden; Lund University, Sweden.
Skåne University Hospital, Sweden; Lund University, Sweden.
Skåne University Hospital, Sweden; Lund University, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 98, nr 5, s. 493-500Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives and MethodsTo ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. ResultsOf the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60years vs. 23% at amp;gt;60years; Pamp;lt;.0001); the median age was 69years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6years) and IR groups (1.7years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5years for +4, 1.9years for +21, 1.5years for +8, 1.1years for +11, and 0.8years for +13 (P=.013). ConclusionAML with single trisomies, with the exception of +13, should be grouped as IR.

Ort, förlag, år, upplaga, sidor
WILEY , 2017. Vol. 98, nr 5, s. 493-500
Nyckelord [en]
acute myeloid leukemia; autosomal trisomy; clinical characteristics; survival
Nationell ämneskategori
Hematologi
Identifikatorer
URN: urn:nbn:se:liu:diva-137596DOI: 10.1111/ejh.12861ISI: 000399882100009PubMedID: 28152233OAI: oai:DiVA.org:liu-137596DiVA, id: diva2:1097375
Anmärkning

Funding Agencies|Vetenskapsradet; Cancerfonden; Regional Cancer Centers; Swedish Association of Local Authorities and Regions (SKL); Governmental Funding of Clinical Research within the National Health Service

Tillgänglig från: 2017-05-22 Skapad: 2017-05-22 Senast uppdaterad: 2017-05-22

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Antunovic, Petar
Av organisationen
Avdelningen för Kirurgi, Ortopedi och OnkologiMedicinska fakultetenHematologiska kliniken US
I samma tidskrift
European Journal of Haematology
Hematologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 181 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf