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Developing organ-on-a-chip concepts using bio-mechatronic design methodology
Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-5914-2837
Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-9711-794X
2017 (engelsk)Inngår i: Biofabrication, ISSN 1758-5082, E-ISSN 1758-5090, Vol. 9, nr 2, artikkel-id 025023Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mechatronic design is an engineering methodology for conceiving, configuring and optimising the design of a technical device or product to the needs and requirements of the final user. In this article, we show how the basic principles of this methodology can be exploited for in vitro cell cultures-often referred to as organ-on-a-chip devices. Due to the key role of the biological cells, we have introduced the term bio-mechatronic design, to highlight the complexity of designing a system that should integrate biology, mechanics and electronics in the same device structure. The strength of the mechatronic design is to match the needs of the potential users to a systematic evaluation of overall functional design alternative. It may be especially attractive for organs-on-chips where biological constituents such as cells and tissues in 3D settings and in a fluidic environment should be compared, screened and selected. Through this approach, design solutions ranked to customer needs are generated according to specified criteria, thereby defining the key constraints of the fabrication. As an example, the bio-mechatronic methodology is applied to a liver-on-a-chip based on information extrapolated from previous theoretical and experimental knowledge. It is concluded that the methodology can generate new fabrication solutions for devices, as well as efficient guidelines for refining the design and fabrication of many of todays organ-on-a-chip devices.

sted, utgiver, år, opplag, sider
IOP PUBLISHING LTD , 2017. Vol. 9, nr 2, artikkel-id 025023
Emneord [en]
conceptual design; design optimisation; organ-on-a-chip; physiological tissue models; microfluidics
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-138470DOI: 10.1088/1758-5090/aa71caISI: 000402555300006PubMedID: 28485301OAI: oai:DiVA.org:liu-138470DiVA, id: diva2:1111758
Merknad

Funding Agencies|Innovative Medicines Initiative Joint Undertaking [115439]; European Unions Seventh Framework Programme; EFPIA

Tilgjengelig fra: 2017-06-19 Laget: 2017-06-19 Sist oppdatert: 2019-01-22
Inngår i avhandling
1. Organs-on-chips for the pharmaceutical development process: design perspectives and implementations
Åpne denne publikasjonen i ny fane eller vindu >>Organs-on-chips for the pharmaceutical development process: design perspectives and implementations
2018 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. The aim of this thesis is to explain and discuss these cell culture devices from a design perspective and to experimentally exemplify some of the specific functions that characterize organs-on-chips.

The cells in our body reside in complex environments with chemical and mechanical cues that affect their function and purpose. Such a complex environment is difficult to recreate in the laboratory and has therefore been overlooked in favor of more simple models, i.e. static twodimensional (2D) cell cultures. Numerous recent reports have shown cell culture systems that can resemble the cell’s natural habitat and enhance cell functionality and thereby potentially provide results that better reflects animal and human trials. The way these organs-on-chips improve in vitro cell culture assays is to include e.g. a three-dimensional cell architecture (3D), mechanical stimuli, gradients of oxygen or nutrients, or by combining several relevant cell types that affect each other in close proximity.

The research conducted for this thesis shows how cells in 3D spheroids or in 3D hydrogels can be cultured in perfused microbioreactors. Furthermore, a pump based on electroosmosis, and a method for an objective conceptual design process, is introduced to the field of organs-on-chips.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2018. s. 78
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1907
Emneord
Organs-on-chips, cell culture models, pharmaceutical development, microfluidics
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-145300 (URN)10.3384/diss.diva-145300 (DOI)9789176853597 (ISBN)
Disputas
2018-03-23, Planck, Fysikhuset, Campus Valla, Linköping, 13:30 (engelsk)
Opponent
Veileder
Merknad

I den tryckta versionen är det ena serienamnet felaktigt. I den elektroniska versionen är detta ändrat till korrekt "Linköping Studies in Science and Technology. Dissertations"

Tilgjengelig fra: 2018-02-21 Laget: 2018-02-21 Sist oppdatert: 2019-09-26bibliografisk kontrollert

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