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Prevalence of the mcr-1 colistin resistance gene in extended-spectrum beta-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China
Shandong Centre Disease Control and Prevent, Peoples R China.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten.
Shandong University, Peoples R China; Shandong University, Peoples R China.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten.
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2017 (Engelska)Ingår i: International Journal of Antimicrobial Agents, ISSN 0924-8579, E-ISSN 1872-7913, Vol. 49, nr 4, s. 493-497Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Since its initial discovery in China in 2015, the plasmid-mediated colistin resistance gene mcr-1 has been reported in Escherichia coli isolated from clinical samples, animals and meat worldwide. In this study, 706 extended-spectrum beta-lactamase (ESBL)-producing E. coli from 411 persons were detected in a collection of faecal samples from 1000 rural residents in three counties in Shandong Province, China. These isolates were screened for mcr-1 and phenotypic colistin resistance. The gene was found in 3.5% of the isolates (from 4.9% of persons) from all three counties. All isolates with phenotypic colistin resistance carried mcr-1. These data indicate that commensal carriage of ESBL-producing E. coli with mcr-1 among persons in rural China was already present in 2012 and that mcr-1 was the most important colistin resistance mechanism. Interventions are necessary to minimise further dissemination of mcr-1, which would limit the future usefulness of colistin as a last-resort antibiotic. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE BV , 2017. Vol. 49, nr 4, s. 493-497
Nyckelord [en]
Drug resistance; Bacteria; Colistin; Escherichia coli; Rural China
Nationell ämneskategori
Mikrobiologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:liu:diva-138923DOI: 10.1016/j.ijantimicag.2016.12.018ISI: 000402466600017PubMedID: 28263896OAI: oai:DiVA.org:liu-138923DiVA, id: diva2:1115822
Anmärkning

Funding Agencies|National Natural Science Foundation of China [71073098]; Swedish International Development Cooperation Agency; Swedish Institute for Communicable Disease Control [2010-001861]

Tillgänglig från: 2017-06-27 Skapad: 2017-06-27 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

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Berglund, BjörnNilsson, MaudTärnberg, MariaNilsson, Lennart E
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Avdelningen för mikrobiologi och molekylär medicinMedicinska fakulteten
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International Journal of Antimicrobial Agents
Mikrobiologi inom det medicinska området

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