liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Surgical and not analgesic technique affects postoperative inflammation following colorectal cancer surgery: a prospective, randomized study
Örebro University Hospital, Sweden; Örebro University, Sweden.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Sinnescentrum, Anestesi- och intensivvårdskliniken US.
Örebro University, Sweden.
Lund University, Sweden.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: Colorectal Disease, ISSN 1462-8910, E-ISSN 1463-1318, Vol. 19, nr 6, s. O186-O195Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery. Methods Ninety-six patients scheduled for open or laparoscopic surgery were randomized to epidural analgesia (group E) or patient-controlled intravenous analgesia (group P). Surgery and anaesthesia were standardized in both groups. Plasma cortisol, insulin and serum cytokines [interleukin 1 beta (IL-1 beta), IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, tumour necrosis factor , interferon , granulocyte-macrophage colony-stimulating factor, prostaglandin E-2 and vascular endothelial growth factor] were measured preoperatively (T0), 1-6h postoperatively (T1) and 3-5days postoperatively (T2). Mixed model analysis was used, after logarithmic transformation when appropriate, for analyses of cytokines and stress markers. Results There were no significant differences in any serum cytokine concentration between groups P and E at any time point except for IL-10 which was 87% higher in group P [median and range 4.1 (2.3-9.2) pg/ml] compared to group E [2.6 (1.3-4.7) pg/ml] (P = 0.002) at T1. There was no difference in plasma cortisol and insulin between the groups at any time point after surgery. A significant difference in median serum cytokine concentration was found between open and laparoscopic surgery with higher levels of IL-6, IL-8 and IL-10 at T1 in patients undergoing open surgery compared to laparoscopic surgery. No difference in serum cytokine concentration was detected between the groups or between the surgical technique at T2. Conclusions Open surgery, compared to laparoscopic surgery, has greater impact on these inflammatory mediators than epidural analgesia vs intravenous analgesia.

Ort, förlag, år, upplaga, sidor
WILEY , 2017. Vol. 19, nr 6, s. O186-O195
Nyckelord [en]
Anaesthesia; epidural; surgery; colorectal cancer; inflammation; cytokines
Nationell ämneskategori
Kirurgi
Identifikatorer
URN: urn:nbn:se:liu:diva-138908DOI: 10.1111/codi.13643ISI: 000402674400003PubMedID: 28258664OAI: oai:DiVA.org:liu-138908DiVA, id: diva2:1115882
Anmärkning

Funding Agencies|Regional Research Committee, Orebro-Uppsala Region, Sweden

Tillgänglig från: 2017-06-27 Skapad: 2017-06-27 Senast uppdaterad: 2017-06-27

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Eintrei, ChristinaMyrelid, Pär
Av organisationen
Avdelningen för läkemedelsforskningMedicinska fakultetenAnestesi- och intensivvårdskliniken USAvdelningen för Kirurgi, Ortopedi och OnkologiKirurgiska kliniken US
I samma tidskrift
Colorectal Disease
Kirurgi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 125 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf