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Effect of platelet-rich plasma on rat Achilles tendon healing is related to microbiota
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. CAPES Fdn, Brazil; Pontificia University of Catolica Rio Grande do Sul PUCRS, Brazil.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 88, no 4, p. 416-421Article in journal (Refereed) Published
Abstract [en]

Background and purpose - In 3 papers in Acta Orthopaedica 10 years ago, we described that platelet-rich plasma (PRP) improves tendon healing in a rat Achilles transection model. Later, we found that microtrauma has similar effects, probably acting via inflammation. This raised the suspicion that the effect ascribed to growth factors within PRP could instead be due to unspecific influences on inflammation. While testing this hypothesis, we noted that the effect seemed to be related to the microbiota. Material and methods - We tried to reproduce our old findings with local injection of PRP 6h after tendon transection, followed by mechanical testing after 11 days. This failed. After fruitless variations in PRP production protocols, leukocyte concentration, and physical activity, we finally tried rats carrying potentially pathogenic bacteria. In all, 242 rats were used. Results - In 4 consecutive experiments on pathogen-free rats, no effect of PRP on healing was found. In contrast, apparently healthy rats carrying Staphylococcus aureus showed increased strength of the healing tendon after PRP treatment. These rats had higher levels of cytotoxic T-cells in their spleens. Interpretation - The failure to reproduce older experiments in clean rats was striking, and the difference in response between these and Staphylococcus-carrying rats suggests that the PRP effect is dependent on the immune status. PRP functions may be more complex than just the release of growth factors. Extrapolation from our previous findings with PRP to the situation in humans therefore becomes even more uncertain.1

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 88, no 4, p. 416-421
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-139667DOI: 10.1080/17453674.2017.1293447ISI: 000404588400010PubMedID: 28296518OAI: oai:DiVA.org:liu-139667DiVA, id: diva2:1133531
Note

Funding Agencies|CAPES-the Brazilian Federal Agency for Support and Evaluation of Graduate Education within the Ministry of Education of Brazil, at Linkoping University

Available from: 2017-08-16 Created: 2017-08-16 Last updated: 2017-09-04

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Dietrich, FrancieleHammerman, MalinBlomgran, ParmisTätting, LoveAspenberg, Per
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Orthopaedics in Linköping
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