liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Slow brushing reduces heat pain in humans
University of Gothenburg, Sweden.
VA San Francisco Healthcare Syst, CA USA; University of Calif San Francisco, CA 94143 USA.
Harvard Medical Sch, MA USA; University of Oslo, Norway.
Justus Liebig University, Germany.
Vise andre og tillknytning
2017 (engelsk)Inngår i: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 21, nr 7, s. 1173-1185Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: C-tactile (CT) afferents are unmyelinated low-threshold mechanoreceptors optimized for signalling affective, gentle touch. In three separate psychophysical experiments, we examined the contribution of CT afferents to pain modulation. Methods: In total, 44 healthy volunteers experienced heat pain and CT optimal (slow brushing) and CT sub-optimal (fast brushing or vibration) stimuli. Three different experimental paradigms were used: Concurrent application of heat pain and tactile (slow brushing or vibration) stimulation; Slow brushing, applied for variable duration and intervals, preceding heat pain; Slow versus fast brushing preceding heat pain. Results: Slow brushing was effective in reducing pain, whereas fast brushing or vibration was not. The reduction in pain was significant not only when the CT optimal touch was applied simultaneously with the painful stimulus but also when the two stimuli were separated in time. For subsequent stimulation, the pain reduction was more pronounced for a shorter time interval between brushing and pain. Likewise, the effect was more robust when pain was preceded by a longer duration of brush stimulation. Strong CT-related pain reduction was associated with low anxiety and high calmness scores obtained by a state anxiety questionnaire. Conclusions: Slow brushing - optimal for CT activation - is effective in reducing pain from cutaneous heating. The precise mechanisms for the pain relief are as yet unknown but possible mechanisms include inhibition of nociceptive projection neurons at the level of the dorsal horn as well as analgesia through cortical mechanisms.

sted, utgiver, år, opplag, sider
WILEY , 2017. Vol. 21, nr 7, s. 1173-1185
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-139904DOI: 10.1002/ejp.1018ISI: 000406872000008PubMedID: 28263013OAI: oai:DiVA.org:liu-139904DiVA, id: diva2:1135757
Merknad

Funding Agencies|IASP - Scan|Design Foundation by Inger Jens Bruun; Swedish Research Council; Marianne and Marcus Wallenberg Foundation; Swedish Brain Foundation; European Neurological Society; German Research Foundation [Bi 579/1, Bi 579/4]

Tilgjengelig fra: 2017-08-24 Laget: 2017-08-24 Sist oppdatert: 2018-05-02

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Nagi, Saad

Søk i DiVA

Av forfatter/redaktør
Nagi, SaadOlausson, Håkan
Av organisasjonen
I samme tidsskrift
European Journal of Pain

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 82 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf