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Dual action of bacteriocin PLNC8 alpha beta through inhibition of Porphyromonas gingivalis infection and promotion of cell proliferation
Örebro University, Sweden.
Karolinska Institutet, Sweden.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär fysik. Linköpings universitet, Tekniska fakulteten. Örebro University, Sweden.ORCID-id: 0000-0002-1781-1489
Örebro University, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Pathogens and Disease, E-ISSN 2049-632X, Vol. 75, nr 5, artikkel-id ftx064Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Periodontitis is a chronic inflammatory disease that is characterised by accumulation of pathogenic bacteria, including Porphyromonas gingivalis, in periodontal pockets. The lack of effective treatments has emphasised in an intense search for alternative methods to prevent bacterial colonisation and disease progression. Bacteriocins are bacterially produced antimicrobial peptides gaining increased consideration as alternatives to traditional antibiotics. We show rapid permeabilisation and aggregation of P. gingivalis by the two-peptide bacteriocin PLNC8 alpha beta. In a cell culture model, P. gingivalis was cytotoxic against gingival fibroblasts. The proteome profile of fibroblasts is severely affected by P. gingivalis, including induction of the ubiquitin-proteasome pathway. PLNC8 alpha beta enhanced the expression of growth factors and promoted cell proliferation, and suppressed proteins associated with apoptosis. PLNC8 alpha beta efficiently counteracted P. gingivalis-mediated cytotoxicity, increased expression of a large number of proteins and restored the levels of inflammatory mediators. In conclusion, we show that bacteriocin PLNC8 alpha beta displays dual effects by acting as a potent antimicrobial agent killing P. gingivalis and as a stimulatory factor promoting cell proliferation. We suggest preventive and therapeutical applications of PLNC8 alpha beta in periodontitis to supplement the host immune defence against P. gingivalis infection and support wound healing processes.

sted, utgiver, år, opplag, sider
OXFORD UNIV PRESS , 2017. Vol. 75, nr 5, artikkel-id ftx064
Emneord [en]
Porphyromonas gingivalis; periodontitis; cell proliferation; proteomics; bacteriocin; PLNC8
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-140072DOI: 10.1093/femspd/ftx064ISI: 000407245300014PubMedID: 28605543OAI: oai:DiVA.org:liu-140072DiVA, id: diva2:1136589
Merknad

Funding Agencies|Foundation of Magnus Bergvall [2015-00823]; Knowledge Foundation, Sweden [20150244, 20150086]

Tilgjengelig fra: 2017-08-28 Laget: 2017-08-28 Sist oppdatert: 2019-01-22

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