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Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register
Karolinska Institute, Sweden.
Regional Cancer Centre West, Sweden.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
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2017 (Engelska)Ingår i: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 99, nr 3, s. 216-222Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Solitary plasmacytoma (SP) and plasma cell leukemia (PCL) are uncommon (3-6%) types of plasma cell disease. The risk of progression to symptomatic multiple myeloma (MM) is probably important for the outcome of SP. PCL is rare and has a dismal outcome. In this study, we report on incidence and survival in PCL/SP, and progression to MM in SP, using the prospective observational Swedish Multiple Myeloma Register designed to document all newly diagnosed plasma cell diseases in Sweden since 2008. Both solitary bone plasmacytoma (SBP) (n=124) and extramedullary plasmacytoma (EMP) (n=67) have better overall survival (OS) than MM (n=3549). Progression to MM was higher in SBP than in EMP (35% and 7% at 2years, respectively), but this did not translate into better survival in EMP. In spite of treatment developments, the OS of primary PCL is still dismal (median of 11months, 0% at 5years). Hence, there is a great need for diagnostic and treatment guidelines as well as prospective studies addressing the role for alternative treatment options, such as allogeneic stem cell transplantation and monoclonal antibodies in the treatment of PCL.

Ort, förlag, år, upplaga, sidor
WILEY , 2017. Vol. 99, nr 3, s. 216-222
Nyckelord [en]
multiple myeloma; plasma cell neoplasms
Nationell ämneskategori
Hematologi
Identifikatorer
URN: urn:nbn:se:liu:diva-140792DOI: 10.1111/ejh.12907ISI: 000408148200003PubMedID: 28544116OAI: oai:DiVA.org:liu-140792DiVA, id: diva2:1140980
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Funding Agencies|Cancerfonden

Tillgänglig från: 2017-09-13 Skapad: 2017-09-13 Senast uppdaterad: 2018-04-18

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Svensson, Ronald

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