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Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Department Lab Med, Sweden.
Division of Medical Diagnostics, Department of Clinical Physiology, Region Jönköping County, Jönköping, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Department of Surgery, Region Jönköping County, Sweden.
Jonköping University, Sweden.
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2017 (engelsk)Inngår i: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 23, nr 34, s. 6212-6219Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer (CRC) surgery with survival. METHODS Plasma levels from 174 CRC patients (69 females and 105 men), with median age 70 years (range 29-90), localized in the colon (n = 105) or rectum (n = 69), with stage. (n = 24), stage. (n = 54), stage. (n = 67) and stage. (n = 29) were measured using commercially available Bio-Plex Pro (TM) Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality. RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-alpha remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-gamma, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-alpha and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20. CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis.

sted, utgiver, år, opplag, sider
BAISHIDENG PUBLISHING GROUP INC , 2017. Vol. 23, nr 34, s. 6212-6219
Emneord [en]
Colorectal cancer; Inflammation; Cytokines; Plasma; Prognosis; Mortality
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Identifikatorer
URN: urn:nbn:se:liu:diva-141715DOI: 10.3748/wjg.v23.i34.6212ISI: 000410751600003OAI: oai:DiVA.org:liu-141715DiVA, id: diva2:1147316
Merknad

Funding Agencies|Foundation of clinical Cancer Research, Jonkoping [151124-6]; Research Council of Southeastern Sweden [FORSS-373251]; FORSS

Tilgjengelig fra: 2017-10-05 Laget: 2017-10-05 Sist oppdatert: 2018-04-19

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