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Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice
Health Science University of Hokkaido, Japan; Taipei Medical University, Taiwan.
Health Science University of Hokkaido, Japan.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Far Eastern Federal University, Russia.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
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2017 (Engelska)Ingår i: Oxidative Medicine and Cellular Longevity, ISSN 1942-0900, E-ISSN 1942-0994, artikel-id 1956104Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose. Astaxanthin (AST) has a strong antioxidant cellular membrane chaperone protective effect. Recently, a water-soluble nanosized AST (nano-AST) form was produced, which is expected to improve the efficacy of oral intake effects. The purpose of this study was to examine whether oral nano-AST has therapeutic effects on UV-induced photokeratitis in mice. Methods. C57BL/6 mice were administered twice with either nano-AST, AST oil, lutein, or bilberry extracts 3 hours before and shortly before UV irradiation (dose: 400 mJ/cm2). The corneas were collected 24 hours after irradiation and stained with Hamp;E and TUNEL. NF-kappa B, dihydroethidium (DHE), COX-2, p-I kappa B-alpha, TNF alpha, and CD45 expression were evaluated through immunohistochemistry, Western blot analysis, and qPCR. Results. Corneal epithelium was significantly thicker in mice orally administered with nano-AST than in the others (p amp;lt; 0.01), with significantly less NF-kappa B nucleus translocation (p amp;lt; 0.001), and significantly fewer TUNEL cells (p amp;lt; 0.01). Weaker DHE signals were detected in the nano-AST group (p amp;lt; 0.05) relative to the others. Furthermore, reduced inflammation and decreased cell death in corneal tissue were observed in the nano-AST group, as indicated by a reduction in the expression of COX-2, p-I kappa B-alpha, TNFa, and CD45. Conclusions. Oral administration of nano-AST demonstrated a protective effect on UV-induced photokeratitis via antioxidative, anti-inflammatory, and antiapoptotic activity.

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HINDAWI LTD , 2017. artikel-id 1956104
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Immunologi
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URN: urn:nbn:se:liu:diva-141943DOI: 10.1155/2017/1956104ISI: 000411941700001OAI: oai:DiVA.org:liu-141943DiVA, id: diva2:1149155
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Funding Agencies|FUJIFILM Inc.; FUJIFILM Corporation

Tillgänglig från: 2017-10-13 Skapad: 2017-10-13 Senast uppdaterad: 2018-09-05

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Mukwaya, Anthony

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Lennikov, AntonMukwaya, AnthonySchaupper, MiraLagali, Neil
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Avdelningen för neuro- och inflammationsvetenskapMedicinska fakultetenÖgonkliniken US/LiM
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Oxidative Medicine and Cellular Longevity
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