Label free optical sensor for Avidin based on single gold nanoparticles functionalized with aptamersVisa övriga samt affilieringar
2009 (Engelska)Ingår i: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648, Vol. 2, nr 4, s. 227-231Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Optical spectroscopy of a single gold nanoparticle, functionalized with an aptamer, is used to sense the specific binding of avidin. Herewith, the field of single noble metal nanoparticle biosensors is extended to the important field of aptamer based assays. The sensitivity of this initial, but not yet optimized apta-nano-sensor is in the range of 20 nM. Due to its nanoscopic size, this single nanoparticle based apta-sensor may be used in nanoscopic volumes such as in array type assays or even inside cells.
Ort, förlag, år, upplaga, sidor
Wiley-VCH Verlagsgesellschaft, 2009. Vol. 2, nr 4, s. 227-231
Nyckelord [en]
apatamer, gold nanoparticles, biosensing
Nationell ämneskategori
Biofysik
Identifikatorer
URN: urn:nbn:se:liu:diva-142958DOI: 10.1002/jbio.200910006ISI: 000265856000009PubMedID: 19367590Scopus ID: 2-s2.0-66949168506OAI: oai:DiVA.org:liu-142958DiVA, id: diva2:1156474
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