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Thermo-rheological responsive microcapsules for time-dependent controlled release of human mesenchymal stromal cells
Linköpings universitet, Institutionen för fysik, kemi och biologi, Sensor- och aktuatorsystem. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten.ORCID-id: 0000-0003-3274-6029
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten.
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2017 (Engelska)Ingår i: Biomaterials Science, ISSN 2047-4830, E-ISSN 2047-4849, Vol. 5, nr 11, s. 2241-2250Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Human mesenchymal stromal cells (hMSCs) are adult-source cells that have been extensively evaluated for cell-based therapies. hMSCs delivered by intravascular injection have been reported to accumulate at the sites of injury to promote tissue repair and can also be employed as vectors for the delivery of therapeutic genes. However, the full potential of hMSCs remains limited as the cells are lost after injection due to anoikis and the adverse pathologic environment. Encapsulation of cells has been proposed as a means of increasing cell viability. However, controlling the release of therapeutic cells over time to target tissue still remains a challenge today. Here, we report the design and development of thermo-rheological responsive hydrogels that allow for precise, time dependent controlled-release of hMSCs. The encapsulated hMSCs retained good viability from 76% to 87% dependent upon the hydrogel compositions. We demonstrated the design of different blended hydrogel composites with modulated strength (S parameter) and looseness of hydrogel networks (N parameter) to control the release of hMSCs from thermoresponsive hydrogel capsules. We further showed the feasibility for controlled-release of encapsulated hMSCs within 3D matrix scaffolds. We reported for the first time by a systematic analysis that there is a direct correlation between the thermo-rheological properties associated with the degradation of the hydrogel composite and the cell release kinetics. This work therefore provides new insights into the further development of smart carrier systems for stem cell therapy.

Ort, förlag, år, upplaga, sidor
ROYAL SOC CHEMISTRY , 2017. Vol. 5, nr 11, s. 2241-2250
Nationell ämneskategori
Biomaterialvetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-143087DOI: 10.1039/c7bm00663bISI: 000413769500005PubMedID: 28972602OAI: oai:DiVA.org:liu-143087DiVA, id: diva2:1159426
Anmärkning

Funding Agencies|Swedish Foundation for Strategic Research [RBP14-0028]

Tillgänglig från: 2017-11-22 Skapad: 2017-11-22 Senast uppdaterad: 2019-02-11

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Mak, Wing CheungMagne, B.Cheung, KittAtanasova, DianaGriffith, May
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Sensor- och aktuatorsystemTekniska fakultetenInstitutionen för klinisk och experimentell medicinMedicinska fakultetenAvdelningen för cellbiologi
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