liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Axonal and myelinic pathology in 5xFAD Alzheimers mouse spinal cord
University of Calgary, Canada.
University of Calgary, Canada.
University of Calgary, Canada.
University of Calgary, Canada.
Vise andre og tillknytning
2017 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, nr 11, artikkel-id e0188218Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

As an extension of the brain, the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology. The brain and cord share the same cellular components, yet the latter is simpler in cytoarchitecture and connectivity. In Alzheimers research, virtually all focus is on brain pathology, however it has been shown that transgenic Alzheimers mouse models accumulate beta amyloid plaques in spinal cord, suggesting that the cord possesses the same molecular machinery and conditions for plaque formation. Here we report a spatial-temporal map of plaque load in 5xFAD mouse spinal cord. We found that plaques started to appear at 11 weeks, then exhibited a time dependent increase and differential distribution along the cord. More plaques were found in cervical than other spinal levels at all time points examined. Despite heavy plaque load at 6 months, the number of cervical motor neurons in 5xFAD mice is comparable to wild type littermates. On detailed microscopic examination, fine beta amyloid-containing and beta sheet-rich thread-like structures were found in the peri-axonal space of many axons. Importantly, these novel structures appear before any plaque deposits are visible in young mice spinal cord and they co-localize with axonal swellings at later stages, suggesting that these thread-like structures might represent the initial stages of plaque formation, and could play a role in axonal damage. Additionally, we were able to demonstrate increasing myelinopathy in aged 5xFAD mouse spinal cord using the lipid probe Nile Red with high resolution. Collectively, we found significant amyloid pathology in grey and white matter of the 5xFAD mouse spinal cord which indicates that this structure maybe a useful platform to study mechanisms of Alzheimers pathology and disease progression.

sted, utgiver, år, opplag, sider
PUBLIC LIBRARY SCIENCE , 2017. Vol. 12, nr 11, artikkel-id e0188218
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-143938DOI: 10.1371/journal.pone.0188218ISI: 000416291900046PubMedID: 29176903OAI: oai:DiVA.org:liu-143938DiVA, id: diva2:1169769
Merknad

Funding Agencies|Dr. Frank Leblanc Chair for Spinal Cord Research; Canadian Institutes of Health Research (CIHR); Canada Research Chairs (CRC); Alberta Prion Research Institute (APRI)

Tilgjengelig fra: 2017-12-29 Laget: 2017-12-29 Sist oppdatert: 2018-01-26

Open Access i DiVA

fulltext(29909 kB)46 nedlastinger
Filinformasjon
Fil FULLTEXT02.pdfFilstørrelse 29909 kBChecksum SHA-512
3768a32e5b76467526820a3f4306f9063de93583d53a844058804fb61cfd0633cefddac34ff481cb6b652691d4f802983720656120537149f50609b7a86f59df
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Nilsson, Peter
Av organisasjonen
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 46 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 71 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf