The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan childrenShow others and affiliations
2018 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 8, article id 1502Article in journal (Refereed) Published
Abstract [en]
Histo-blood group antigens (HBGAs) and the Lewis and secretor antigens are associated with susceptibility to rotavirus infection in a genotype-dependent manner. Nicaraguan children were prospectively enrolled in two cohorts vaccinated with either RotaTeq RV5 (n = 68) or Rotarix RV1 (n = 168). Lewis and secretor antigens were determined by saliva phenotyping and genotyping. Seroconversion was defined as a 4-fold increase in plasma IgA antibody titer 1 month after administration of the first dose of the vaccine. Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P amp;lt; 0.01). Furthermore, following administration of the RV1 vaccine, secretor-positive ABO blood group B children seroconverted to a significantly lesser extent (5%) compared to secretor-positive children with ABO blood groups A (26%) and O (27%) (P amp;lt; 0.05). Other factors such as pre-vaccination titers, sex, breastfeeding, and calprotectin levels did not influence vaccine-take. Differences in HBGA expression appear to be a contributing factor in the discrepancy in vaccine-take and thus, in vaccine efficacy in different ethnic populations.
Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 8, article id 1502
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-145130DOI: 10.1038/s41598-018-19718-yISI: 000423154000032PubMedID: 29367698OAI: oai:DiVA.org:liu-145130DiVA, id: diva2:1183659
Note
Funding Agencies|Swedish Research Council [348-2013-6587, 2011-3469-90642-57]
2018-02-192018-02-192022-09-15