liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Age-Related Vascular Changes Affect Turbulence in Aortic Blood Flow
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Kangwon Natl Univ, South Korea.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-9184-9234
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Show others and affiliations
2018 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 36Article in journal (Refereed) Published
Abstract [en]

Turbulent blood flow is implicated in the pathogenesis of several aortic diseases but the extent and degree of turbulent blood flow in the normal aorta is unknown. We aimed to quantify the extent and degree of turbulece in the normal aorta and to assess whether age impacts the degree of turbulence. 22 young normal males (23.7 +/- 3.0 y.o.) and 20 old normal males (70.9 +/- 3.5 y.o.) were examined using four dimensional flow magnetic resonance imaging (4D Flow MRI) to quantify the turbulent kinetic energy (TKE), a measure of the intensity of turbulence, in the aorta. All healthy subjects developed turbulent flow in the aorta, with total TKE of 3-19 mJ. The overall degree of turbulence in the entire aorta was similar between the groups, although the old subjects had about 73% more total TKE in the ascending aorta compared to the young subjects (young = 3.7 +/- 1.8 mJ, old = 6.4 +/- 2.4 mJ, p amp;lt; 0.001). This increase in ascending aorta TKE in old subjects was associated with age-related dilation of the ascending aorta which increases the volume available for turbulence development. Conversely, age-related dilation of the descending and abdominal aorta decreased the average flow velocity and suppressed the development of turbulence. In conclusion, turbulent blood flow develops in the aorta of normal subjects and is impacted by age-related geometric changes. Non-invasive assessment enables the determination of normal levels of turbulent flow in the aorta which is a prerequisite for understanding the role of turbulence in the pathophysiology of cardiovascular disease.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2018. Vol. 9, article id 36
Keywords [en]
turbulent kinetic energy (TKE); turbulent blood flow; aortic blood flow; aortic dilation; normal values; 4D flow MRI; phase contrast MRI
National Category
Physiology
Identifiers
URN: urn:nbn:se:liu:diva-145129DOI: 10.3389/fphys.2018.00036ISI: 000423400000001PubMedID: 29422871OAI: oai:DiVA.org:liu-145129DiVA, id: diva2:1183661
Note

Funding Agencies|Swedish Research Council [2013-6077, 2014-6191]; Swedish Heart and Lung foundation [20140398]; Kangwon National University [D1001179-01-01]; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2016R1A6A3A03006337]

Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2019-04-17
In thesis
1. Improving Assessments of Hemodynamics and Vascular Disease
Open this publication in new window or tab >>Improving Assessments of Hemodynamics and Vascular Disease
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Blood vessels are more than simple pipes, passively enabling blood to pass through them. Their form and function are dynamic, changing with both aging and disease. This process involves a feedback loop wherein changes to the shape of a blood vessel affect the hemodynamics, causing yet more structural adaptation. This feedback loop is driven in part by the hemodynamic forces generated by the blood flow, and the distribution and strength of these forces appear to play a role in the initiation, progression, severity, and the outcome of vascular diseases.

Magnetic Resonance Imaging (MRI) offers a unique platform for investigating both the form and function of the vascular system. The form of the vascular system can be examined using MR-based angiography, to generate detailed geometric analyses, or through quantitative techniques for measuring the composition of the vessel wall and atherosclerotic plaques. To complement these analyses, 4D Flow MRI can be used to quantify the functional aspect of the vascular system, by generating a full time-resolved three-dimensional velocity field that represents the blood flow.

This thesis aims to develop and evaluate new methods for assessing vascular disease using novel hemodynamic markers generated from 4D Flow MRI and quantitative MRI data towards the larger goal of a more comprehensive non-invasive examination oriented towards vascular disease. In Paper I, we developed and evaluated techniques to quantify flow stasis in abdominal aortic aneurysms to measure this under-explored aspect of aneurysmal hemodynamics. In Paper II, the distribution and intensity of turbulence in the aorta was quantified in both younger and older men to understand how aging changes this aspect of hemodynamics. A method to quantify the stresses generated by turbulence that act on the vessel wall was developed and evaluated using simulated flow data in Paper III, and in Paper V this method was utilized to examine the wall stresses of the carotid artery. The hemodynamics of vascular disease cannot be uncoupled from the anatomical changes the vessel wall undergoes, and therefore Paper IV developed and evaluated a semi-automatic method for quantifying several aspects of vessel wall composition. These developments, taken together, help generate more valuable information from imaging data, and can be pooled together with other methods to form a more comprehensive non-invasive examination for vascular disease.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2019. p. 64
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1675
National Category
Medical Image Processing Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:liu:diva-156311 (URN)10.3384/diss.diva-156311 (DOI)9789176850985 (ISBN)
Public defence
2019-05-31, Hugo Theorell, Norra Entrén, Campus US, Linköping, 13:00 (English)
Opponent
Supervisors
Funder
Swedish Research Council, 2013-06077Swedish Research Council, 2017-03857Region Östergötland, LIO-752951
Available from: 2019-04-17 Created: 2019-04-12 Last updated: 2019-04-24Bibliographically approved

Open Access in DiVA

fulltext(3021 kB)66 downloads
File information
File name FULLTEXT01.pdfFile size 3021 kBChecksum SHA-512
036d971ecfbeef902838c452b786888f593b5f4d97dc267b5430d83d28fe5659019d8eff32e54524ee0afc95e1c46fa90cf6bf9951133131cda3c980c6087029
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Bjarnegård, Niclas

Search in DiVA

By author/editor
Ha, HojinZiegler, MagnusWelander, MartinBjarnegård, NiclasCarlhäll, CarljohanLindenberger, MarcusLänne, TosteEbbers, TinoDyverfeldt, Petter
By organisation
Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Thoracic and Vascular SurgeryDepartment of Clinical Physiology in LinköpingDepartment of Cardiology in Linköping
In the same journal
Frontiers in Physiology
Physiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 66 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 573 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf