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Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide epsilon-poly-L-Lysine
Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär fysik. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär fysik. Linköpings universitet, Tekniska fakulteten. S2Med AB, Linnegatan 9, SE-58225 Linkoping, Sweden.
Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten. S2Med AB, Linnegatan 9, SE-58225 Linkoping, Sweden.
Orebro Univ, Sweden.
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2018 (engelsk)Inngår i: Biomedical Materials, ISSN 1748-6041, E-ISSN 1748-605X, Vol. 13, nr 2, artikkel-id 025014Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Wound dressings based on bacterial cellulose (BC) can form a soft and conformable protective layer that can stimulate wound healing while preventing bacteria from entering the wound. Bacteria already present in the wound can, however, thrive in the moist environment created by the BC dressing which can aggravate the healing process. Possibilities to render the BC antimicrobial without affecting the beneficial structural and mechanical properties of the material would hence be highly attractive. Here we present methods for functionalization of BC with epsilon-poly-L-Lysine (epsilon-PLL), a non-toxic biopolymer with broad-spectrum antimicrobial activity. Low molecular weight epsilon-PLL was crosslinked in pristine BC membranes and to carboxymethyl cellulose functionalized BC using carbodiimide chemistry. The functionalization of BC with epsilon-PLL inhibited growth of S. epidermidis on the membranes but did not affect the cytocompatibility to cultured human fibroblasts as compared to native BC. The functionalization had no significant effects on the nanofibrous structure and mechanical properties of the BC. The possibility to functionalize BC with epsilon-PLL is a promising, green and versatile approach to improve the performance of BC in wound care and other biomedical applications.

sted, utgiver, år, opplag, sider
IOP PUBLISHING LTD , 2018. Vol. 13, nr 2, artikkel-id 025014
Emneord [en]
bacterial cellulose; antimicrobial; carboxymethyl cellulose; epsilon-poly-L-Lysine
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Identifikatorer
URN: urn:nbn:se:liu:diva-145234DOI: 10.1088/1748-605X/aa9486ISI: 000423860700006PubMedID: 29047451OAI: oai:DiVA.org:liu-145234DiVA, id: diva2:1184450
Merknad

Funding Agencies|Linkoping University [2009 00971]; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009 00971]; Carl Trygger Foundation; Knowledge Foundation

Tilgjengelig fra: 2018-02-21 Laget: 2018-02-21 Sist oppdatert: 2019-01-22

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