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The relationship between forearm skin speed-resolved perfusion and oxygen saturation, and finger arterial pulsation amplitudes, as indirect measures of endothelial function
Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-9663-3720
CNR Inst Clin Physiol, Italy.
CNR Inst Clin Physiol, Italy.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-6385-6760
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2018 (English)In: Microcirculation, ISSN 1073-9688, E-ISSN 1549-8719, Vol. 25, no 2, article id e12422Article in journal (Refereed) Published
Abstract [en]

Objective: Endothelial function is important for regulating peripheral blood flow to meet varying metabolic demands and can be measured indirectly during vascular provocations. In this study, we compared the PAT finger response (EndoPAT) after a 5-minutes arterial occlusion to that from forearm skin comprehensive microcirculation analysis (EPOS). Methods: Measurements in 16 subjects with varying cardiovascular risk factors were carried out concurrently with both methods during arterial occlusion, while forearm skin was also evaluated during local heating. Results: Peak values for EPOS skin Perf(conv) and speed-resolved total perfusion after the release of the occlusion were significantly correlated to the EndoPAT RHI (rho =.68, P = .007 and rho =.60, P = .025, respectively), mainly due to high-speed blood flow. During local heating, EPOS skin oxygen saturation, SO2, was significantly correlated to RHI (rho = .62, P =.043). This indicates that SO2 may have diagnostic value regarding endothelial function. Conclusions: We have demonstrated for the first time a significant relationship between forearm skin microcirculatory perfusion and oxygen saturation and finger PAT. Both local heating and reactive hyperemia are useful skin provocations. Further studies are needed to understand the precise regulation mechanisms of blood flow and oxygenation during these tests.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 25, no 2, article id e12422
Keywords [en]
diffuse reflectance spectroscopy; endothelium; laser Doppler Flowmetry; reactive hyperemia; tissue oxygenation
National Category
Physiology
Identifiers
URN: urn:nbn:se:liu:diva-145476DOI: 10.1111/micc.12422ISI: 000424813900002PubMedID: 29044805OAI: oai:DiVA.org:liu-145476DiVA, id: diva2:1188353
Note

Funding Agencies|European Union Seventh Framework Programme (FP7) [611516]; Fulbright Visiting Scholar grant; Swedish Governmental Agency for Innovation Systems [VINNOVA] [2016-02211]

Available from: 2018-03-07 Created: 2018-03-07 Last updated: 2018-03-07

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