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Solenoid Driven Pressure Valve System: Toward Versatile Fluidic Control in Paper Microfluidics
DGIST, South Korea.
Samsung Elect, South Korea.
DGIST, South Korea.
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering. DGIST, South Korea.
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2018 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 90, no 4, p. 2534-2541Article in journal (Refereed) Published
Abstract [en]

As paper-based diagnostics has become predominantly driven by more advanced microfluidic technology, many of the research efforts are still focused on developing reliable and versatile fluidic control devices, apart from improving sensitivity and reproducibility. In this work, we introduce a novel and robust paper fluidic control system enabling versatile fluidic control. The system comprises a linear push-pull solenoid and an Arduino Uno micro controller. The precisely controlled pressure exerted on the paper stops the flow. We first determined the stroke distance of the solenoid to obtain a constant pressure while examining the fluidic time delay as a function of the pressure. Results showed that strips of grade 1 chromatography paper had superior reproducibility in fluid transport. Next, we characterized the reproducibility of the fluidic velocity which depends on the type and grade of paper used. As such, we were able to control the flow velocity on the paper and also achieve a complete stop of flow with a pressure over 2.0 MPa. Notably, after the actuation of the pressure driven valve (PDV), the previously pressed area regained its original flow properties. This means that, even on a previously pressed area, multiple valve operations can be successfully conducted. To the best of our knowledge, this is the first demonstration of an active and repetitive valve operation in paper microfluidics. As a proof of concept, we have chosen to perform a multistep detection system in the form of an enzyme-linked immunosorbent assay with mouse IgG as the target analyte.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2018. Vol. 90, no 4, p. 2534-2541
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:liu:diva-145759DOI: 10.1021/acs.analchem.7b03791ISI: 000426143100022PubMedID: 29365265OAI: oai:DiVA.org:liu-145759DiVA, id: diva2:1192490
Note

Funding Agencies|National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2017M3A9E9072667, NRF-2015R1C1A1A01054292]

Available from: 2018-03-22 Created: 2018-03-22 Last updated: 2018-04-13

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