liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Development and pilot testing of PHARAO-a decision support system for pharmacological risk assessment in the elderly
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology.
Medbase Ltd, Finland; Univ Turku, Finland.
Medbase Ltd, Finland; Univ Turku, Finland.
Medbase Ltd, Finland; Turku Univ Hosp, Finland; Univ Turku, Finland.
Show others and affiliations
2018 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 74, no 3, p. 365-371Article in journal (Refereed) Published
Abstract [en]

The aims of this study are to describe the development of PHARAO (Pharmacological Risk Assessment Online), a decision support system providing a risk profile for adverse events, associated with combined effects of multiple medicines, and to present data from a pilot study, testing the use, functionality, and acceptance of the PHARAO system in a clinical setting. About 1400 substances were scored in relation to their risk to cause any of nine common and/or serious adverse effects. Algorithms for each adverse effect score were developed to create individual risk profiles from the patients list of medication. The system was tested and integrated to the electronic medical record, during a 4-month period in two geriatric wards and three primary healthcare centers, and a questionnaire was answered by the users before and after the test period. A total of 732 substances were tagged with one or more of the nine risks, most commonly with the risk of sedation or seizures. During the pilot, the system was used 933 times in 871 patients. The most common signals generated by PHARAO in these patients were related to the risks of constipation, sedation, and bleeding. A majority of responders considered PHARAO easy to use and that it gives useful support in performing medication reviews. The PHARAO decision support system, designed as a complement to a database on drug-drug interactions used nationally, worked as intended and was appreciated by the users during a 4-month test period. Integration aspects need to be improved to minimize unnecessary signaling.

Place, publisher, year, edition, pages
SPRINGER HEIDELBERG , 2018. Vol. 74, no 3, p. 365-371
Keywords [en]
Adverse drug reaction; Clinical decision support system; Drug interactions; Polypharmacy; Elderly
National Category
Social and Clinical Pharmacy
Identifiers
URN: urn:nbn:se:liu:diva-145442DOI: 10.1007/s00228-017-2391-3ISI: 000424708300013PubMedID: 29198061OAI: oai:DiVA.org:liu-145442DiVA, id: diva2:1192913
Available from: 2018-03-23 Created: 2018-03-23 Last updated: 2018-04-13

Open Access in DiVA

fulltext(730 kB)62 downloads
File information
File name FULLTEXT01.pdfFile size 730 kBChecksum SHA-512
549f9be131a41c2fe54a1f7a94cb7a2b741f9a60fd542a39f68b56184e3eb2ac110c351f9a7f68189d408df7cf6bf7776e26597e646a11dc60c387907c462629
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Böttiger, Ylva
By organisation
Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Clinical Pharmacology
In the same journal
European Journal of Clinical Pharmacology
Social and Clinical Pharmacy

Search outside of DiVA

GoogleGoogle Scholar
Total: 62 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 477 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf