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Sex differences in life span: Females homozygous for the X chromosome do not suffer the shorter life span predicted by the unguarded X hypothesis
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-6112-9586
2018 (engelsk)Inngår i: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 72, nr 3, s. 568-577Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Life span differs between the sexes in many species. Three hypotheses to explain this interesting pattern have been proposed, involving different drivers: sexual selection, asymmetrical inheritance of cytoplasmic genomes, and hemizygosity of the X(Z) chromosome (the unguarded X hypothesis). Of these, the unguarded X has received the least experimental attention. This hypothesis suggests that the heterogametic sex suffers a shortened life span because recessive deleterious alleles on its single X(Z) chromosome are expressed unconditionally. In Drosophila melanogaster, the X chromosome is unusually large (approximate to 20% of the genome), providing a powerful model for evaluating theories involving the X. Here, we test the unguarded X hypothesis by forcing D. melanogaster females from a laboratory population to express recessive X-linked alleles to the same degree as males, using females exclusively made homozygous for the X chromosome. We find no evidence for reduced life span or egg-to-adult viability due to X homozygozity. In contrast, males and females homozygous for an autosome both suffer similar, significant reductions in those traits. The logic of the unguarded X hypothesis is indisputable, but our results suggest that the degree to which recessive deleterious X-linked alleles depress performance in the heterogametic sex appears too small to explain general sex differences in life span.

sted, utgiver, år, opplag, sider
WILEY , 2018. Vol. 72, nr 3, s. 568-577
Emneord [en]
Ageing; Drosophila; life span; sex differences; unguarded X; X chromosome
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-147130DOI: 10.1111/evo.13434ISI: 000427676800011PubMedID: 29430636OAI: oai:DiVA.org:liu-147130DiVA, id: diva2:1199516
Merknad

Funding Agencies|Royal Physiographic Society in Lund; Swedish Research Council; Helge Ax:son Johnsons stiftelse

Tilgjengelig fra: 2018-04-20 Laget: 2018-04-20 Sist oppdatert: 2018-05-23

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