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Lower risk of hip fractures among Swedish women with large hips?
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. University of Gothenburg, Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Parker Inst, Denmark; Bispebjerg and Fredriksberg Hosp, Denmark; Univ Southern Denmark, Denmark; Univ Copenhagen, Denmark.
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2018 (English)In: Osteoporosis International, ISSN 0937-941X, E-ISSN 1433-2965, Vol. 29, no 4, p. 927-935Article in journal (Refereed) Published
Abstract [en]

In women, a large hip circumference (HC) related to lower hip fracture risk, independent of age and regardless if HC was measured long before or closer to the fracture. In older women, body mass index (BMI) explained the protection. In postmenopausal women, HC has been suggested to inversely associate with hip fracture while this has not been investigated in middle-aged women. We examined the association between HC, measured at two different time points, and hip fracture in a Swedish female population-based sample monitored for incident hip fractures over many years. Baseline HC, measured in 1968 or 1974 (n = 1451, mean age 47.6 years), or the HC measures that were the most proximal before event or censoring (n = 1325, mean age 71.7 years), were used to assess the effects of HC on hip fracture risk in women participating in the Prospective Population Study of Women in Gothenburg. HC was parameterized as quintiles with the lowest quintile (Q1) as reference. Incident hip fractures over 45 years of follow-up (n = 257) were identified through hospital registers. Higher quintiles of HC at both baseline and proximal to event were inversely associated with hip fracture risk in age-adjusted models, but only baseline HC predicted hip fractures independently of BMI and other covariates (HR (95% CI) Q2, 0.85 (0.56-1.27); Q3, 0.59 (0.36-0.96); Q4, 0.57 (0.34-0.96); Q5, 0.58 (0.31-1.10)). A large HC is protective against hip fracture in midlife and in advanced age, but the association between proximal HC and hip fracture was explained by concurrent BMI suggesting that padding was not the main mechanism for the association. The independent protection seen in middle-aged women points to other mechanisms influencing bone strength.

Place, publisher, year, edition, pages
SPRINGER LONDON LTD , 2018. Vol. 29, no 4, p. 927-935
Keywords [en]
Body mass index; Hip circumference; Hip fractures; Longitudinal
National Category
Orthopaedics
Identifiers
URN: urn:nbn:se:liu:diva-147085DOI: 10.1007/s00198-017-4363-yISI: 000427631200015PubMedID: 29374771OAI: oai:DiVA.org:liu-147085DiVA, id: diva2:1199577
Note

Funding Agencies|Swedish Research Council FORTE, through its support of EpiLife Center of Excellence

Available from: 2018-04-20 Created: 2018-04-20 Last updated: 2018-05-28

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CiteExportLink to record
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