liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Significant Changes in the Skin Microbiome in Patients with Chronic Plaque Psoriasis after Treatment with Narrowband Ultraviolet B
Div Dermatol and Venereol, Sweden.
Div Dermatol and Venereol, Sweden.
Div Med Diagnost, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Div Med Diagnost, Sweden.
Show others and affiliations
2018 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 98, no 4, p. 428-436Article in journal (Refereed) Published
Abstract [en]

Changes in the skin microbiome have been shown to promote cutaneous inflammation. The skin microbiome of patients with chronic plaque type psoriasis was analysed before and after treatment with narrowband ultraviolet B (UVB). Swab samples of the microbiome were taken from lesional and non-lesional skin of 26 patients. Microbiotas were characterized by sequencing 16S rRNA bacterial genes on the Illumina MiSeq platform. Lesional skin microbiome diversity correlated with psoriasis severity (measured with the Psoriasis Area and Severity Index; PASI). There was a significantly lower abundance of the phylum Firmicutes and the genus Staphylococcus in lesional skin compared with non-lesional skin before UVB treatment. Responders (amp;gt; 75% target Psoriasis Severity Index (PSI) improvement) had significantly lower abundance of the phyla Firmicutes in lesional and non-lesional skin and lower abundance of the genera Staphylococcus, Finegoldia, Anaerococcus, Peptoniphilus, Gardnerella, Prevotella and Clostridium in lesional skin after UVB treatment. Pseudomonas significantly decreased in lesional and non-lesional skin of treatment responders. These results suggest that skin microbiome alterations after UVB treatment could be related to treatment and treatment response.

Place, publisher, year, edition, pages
ACTA DERMATO-VENEREOLOGICA , 2018. Vol. 98, no 4, p. 428-436
Keywords [en]
psoriasis; microbiome; UVB treatment
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-147821DOI: 10.2340/00015555-2859ISI: 000430147800008PubMedID: 29199351OAI: oai:DiVA.org:liu-147821DiVA, id: diva2:1205611
Note

Funding Agencies|Swedish Psoriasis Foundation; Futurum, The Academy of Healthcare, County Council of Jonkoping, Sweden

Available from: 2018-05-14 Created: 2018-05-14 Last updated: 2018-06-04

Open Access in DiVA

fulltext(619 kB)97 downloads
File information
File name FULLTEXT01.pdfFile size 619 kBChecksum SHA-512
77449a67bfc4f1e91c32c0e40706890a0579180d6b4c8328fe367073c7bf11895fbfd1424c6da75e218c37796f2a354a01d237a09e5e7a44dd37420e1fa5edc1
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Söderman, JanSeifert, Oliver
By organisation
Division of Cell BiologyFaculty of Medicine and Health Sciences
In the same journal
Acta Dermato-Venereologica
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar
Total: 97 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 467 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf