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Nanoplasmonic Sensing from the Human Vision Perspective
Nanyang Technol Univ, Singapore.
Nanyang Technol Univ, Singapore; Tsinghua Univ, Peoples R China.
Nanyang Technol Univ, Singapore.
Nanyang Technol Univ, Singapore; Ho Chi Minh City Univ Technol and Educ, Vietnam.
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2018 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 90, no 7, p. 4916-4924Article in journal (Refereed) Published
Abstract [en]

Localized surface plasmon resonance (LSPR) constitutes a versatile technique for biodetection, exploiting the sensitivity of plasmonic nanostructures to small changes in refractive index. The optical shift in the LSPR band caused by molecular interactions in the vicinity of the nanostructures are typically amp;lt;5 nm and can readily be detected by a spectrophotometer. Widespread use of LSPR-based sensors require cost-effective devices and would benefit from sensing schemes that enables use of very simple spectrophotometers or even naked-eye detection. This paper describes a new strategy facilitating visualization of minute optical responses in nanoplasmonic bioassays by taking into account the physiology of human color vision. We demonstrate, using a set of nine different plasmonic nanoparticles, that the cyan to green transition zone at similar to 500 nm is optimal for naked-eye detection of color changes. In this wavelength range, it is possible to detect a color change corresponding to a wavelength shift of similar to 2-3 nm induced by refractive index changes in the medium or by molecular binding to the surface of the nanoparticles. This strategy also can be utilized to improve the performance of aggregation-based nanoplasmonic colorimetric assays, which enables semiquantitative naked-eye detection of matrix metalloproteinase 7 (MMP7) activity at concentrations that are at least 5 times lower than previously reported assays using spherical gold nanoparticles. We foresee significant potential of this strategy in medical diagnostic and environmental monitoring, especially in situations where basic laboratory infrastructure is sparse or even nonexistent. Finally, we demonstrate that the developed concept can be used in combination with cell phone technology and red-green-blue (RGB) analysis for sensitive and quantitative detection of MMP7.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2018. Vol. 90, no 7, p. 4916-4924
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-147805DOI: 10.1021/acs.analchem.8b00597ISI: 000429385800092PubMedID: 29542915OAI: oai:DiVA.org:liu-147805DiVA, id: diva2:1205635
Note

Funding Agencies|iFood initiative at Nanyang Technological University; Institute for Nanomedicine; Northwestern University; Nanyang Technological University; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]

Available from: 2018-05-14 Created: 2018-05-14 Last updated: 2018-05-14

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