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Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes
Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
2018 (English)In: Journal of Diabetes Research, ISSN 2314-6745, E-ISSN 2314-6753, article id 8623560Article in journal (Refereed) Published
Abstract [en]

Background. Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein.

Objective. To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D.

Methods. Ten girls and ten boys with type 1 diabetes (T1D), aged 13.0 +/- 1.4 (mean +/- SD) years at diagnosis, took part in the study. Blood samples were drawn at diagnosis and after 3, 9, 18, and 48 months. HbA1c, total IGF-1, and C-peptide were measured.

Results. At diagnosis, the patients had high HbA1c, low IGF-1, and measurable C-peptide. After the start of insulin treatment, maximal improvement in glycemic control and IGF-1 occurred within 3 months and then both tended to deteriorate, that is, HbA1c to increase and IGF-1 to decrease. C-peptide decreased with time, and after 4 years, half of the patients were C-peptide negative. At diagnosis, C-peptide correlated positively to IGF-1 (r = 0 50; p amp;lt; 0 03). C-peptide correlated negatively with insulin dose (U/kg) after 18 and 48 months from diagnosis (r = -0 48; p amp;lt; 0 03 and r = -0 72; p amp;lt; 0 001, resp.).

Conclusions. In conclusion, our results show that in newly diagnosed adolescents with type 1 diabetes and deranged metabolism, the IGF-1 level is low and rapidly improves with insulin treatment but later tends to decrease concomitantly with declining endogenous insulin secretion.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2018. article id 8623560
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-147455DOI: 10.1155/2018/8623560ISI: 000428896300001PubMedID: 29744370OAI: oai:DiVA.org:liu-147455DiVA, id: diva2:1206240
Note

Funding Agencies|Landstinget Ostergotland; Swedish Medical Research Council [04952]

Available from: 2018-05-16 Created: 2018-05-16 Last updated: 2019-02-28Bibliographically approved

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Simona Chisalita, IoanaLudvigsson, Johnny

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Faculty of Medicine and Health SciencesDepartment of EndocrinologyDivision of Cardiovascular MedicineDivision of Children's and Women's healthH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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