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Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition
School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.
Department for Health Science and Technology, Cartilage Engineering and Regeneration Laboratory, ETH Zurich, Zurich, Switzerland.
Linköpings universitet.
Department for Chemistry and Biotechnology, Tissue Engineering, Zurich University of Applied Sciences, Wädenswil, Switzerland.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Royal Society Open Science, E-ISSN 2054-5703, Vol. 5, nr 3, artikkel-id 171562Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and their nanofibrillar structure. Thus, self assembling peptide hydrogels might be suitable scaffolds for regenerative therapies and tissue engineering. Owing to the use of various peptide concentrations and buffer compositions, the self-assembling peptide hydrogels might be influenced regarding their mechanical characteristics. Therefore, the mechanical properties and stability of a set of self-assembling peptide hydrogels, consisting of 11 amino acids, made from four beta sheet self-assembling peptides in various peptide concentrations and buffer compositions were studied. The formed self-assembling peptide hydrogels exhibited stiffnesses ranging from 0.6 to 205 kPa. The hydrogel stiffeness affected by peptide sequence followed by peptide concentration and buffer composition. All self-assembling peptide hydrogels examined provided a nanofibrillar network formation. A maximum self-assembling peptide hydrogel dissolution of 20% was observed for different buffers solution after 7 days. The stability regarding enzymatic and bacterial digestion showed less degradation in comparison to the self-assembling peptide hydrogel dissolution rate in buffer. The tested set of self-assembling peptide hydrogels were able to form stable scaffolds and provided a broad spectrum of tissue-specific stiffnesses that are suitable for a regenerative therapy.

sted, utgiver, år, opplag, sider
London, United Kingdom: The Royal Society Publishing , 2018. Vol. 5, nr 3, artikkel-id 171562
Emneord [en]
self-assembling peptides (SAP); SAP hydrogel stiffness; nanofibrillar architecture; SAP hydrogel degradability
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-147424DOI: 10.1098/rsos.171562ISI: 000428874600025PubMedID: 29657766Scopus ID: 2-s2.0-85043979918OAI: oai:DiVA.org:liu-147424DiVA, id: diva2:1206591
Merknad

Funding Agencies|credentis AG (Windisch, Switzerland); Commission for Technology and Innovation (CTI, Switzerland) [17310.1 PFLS-LS]; Commission for Technology and Innovation (CTI, Forschungsfond Aargau project, Switzerland) [20150831_11]

Tilgjengelig fra: 2018-05-17 Laget: 2018-05-17 Sist oppdatert: 2018-06-04bibliografisk kontrollert

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