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Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy
Karolinska Inst, Sweden; SCON, Sweden.
Karolinska Inst, Sweden; SCON, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Karolinska Inst, Sweden; Danderyd Hosp, Sweden.
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2018 (English)In: Mediators of Inflammation, ISSN 0962-9351, E-ISSN 1466-1861, article id 3985154Article in journal (Refereed) Published
Abstract [en]

The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (n = 49) or relaxation (n = 43). Baseline IL-2, IL-6, TNF-alpha, IP-10, and eotaxin were higher in FM than in healthy controls (P amp;lt; 0.041), whereas IL-beta was lower (P amp;lt; 0.001). There were weak correlations between cytokine levels and clinical variables. After both interventions, IL-1ra had increased (P=0.004), while IL-1 beta had increased in the relaxation group (P = 0.002). Changes of IFN-gamma, IL-2, IL-4, IL-6, IL-8, and IL-17A were weakly correlated with changes of PPT, but there were no significant correlations between changes of cytokine and changes in other clinical variables. The elevated plasma levels of several cytokines supports the hypothesis that chronic systemic inflammation may underlie the pathophysiology of FM even if the relation to clinical variables was weak. However, 15 weeks of resistance exercise, as performed in this study, did not show any anti-inflammatory effect on neither FM symptoms nor clinical and functional variables.

Place, publisher, year, edition, pages
HINDAWI LTD , 2018. article id 3985154
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Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-147961DOI: 10.1155/2018/3985154ISI: 000431306900001OAI: oai:DiVA.org:liu-147961DiVA, id: diva2:1209457
Note

Funding Agencies|Swedish Rheumatism Association; Swedish Research Council [K2009-52P-20943-03-2, K2011-69X-21874-01-6, K2015-99X-21874-05-05]; Stockholm County Council; County Council of Ostergotland; AFA Insurance; Norrbacka-Eugenia Foundation; Health and Medical Care Executive Board of Vastra Gotaland Region; ALF-LUA at Sahlgrenska University Hospital; Gothenburg Center for Person Centered Care (GPCC)

Available from: 2018-05-23 Created: 2018-05-23 Last updated: 2018-06-19

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