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Insertion sequence transpositions and point mutations in mgrB causing colistin resistance in a clinical strain of carbapenem-resistant Klebsiella pneumoniae from Vietnam
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Vietnam Natl Childrens Hosp, Vietnam.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Vietnam Natl Childrens Hosp, Vietnam.
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2018 (English)In: International Journal of Antimicrobial Agents, ISSN 0924-8579, E-ISSN 1872-7913, Vol. 51, no 5, p. 789-793Article in journal (Refereed) Published
Abstract [en]

Resistance among Klebsiella pneumoniae to the last-resort antibiotics carbapenems and colistin is increasing worldwide. In this study, whole-genome sequencing was used to determine the colistin resistance mechanisms in clinical isolates of carbapenem-and colistin-resistant K. pneumoniae from Vietnam. Alterations in the regulatory gene mgrB, via mutations and insertion sequence transpositions, were found in 30 of 31 isolates, emphasising the importance of this resistance mechanism in colistin-resistant K. pneumoniae. (c) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 51, no 5, p. 789-793
Keywords [en]
Antibiotic resistance; Colistin; Insertion sequence; Klebsiella; mgrB
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-148110DOI: 10.1016/j.ijantimicag.2017.11.012ISI: 000432150700019PubMedID: 29180281OAI: oai:DiVA.org:liu-148110DiVA, id: diva2:1211306
Note

Funding Agencies|Linkoping University (Linkoping, Sweden); Karolinska Institute (Stockholm, Sweden); Training and Research Academic Collaboration (TRAC) Sweden Vietnam; Swedish Foundation for International Cooperation in Research and Higher Education (STINT), ReAct; Swedish Research Council

Available from: 2018-05-30 Created: 2018-05-30 Last updated: 2019-05-01

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Berglund, BjörnTärnberg, MariaSvartström, OlovNilsson, MaudWelander, JennyNilsson, Lennart EHanberger, Håkan
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of Clinical and Experimental MedicineDepartment of Clinical MicrobiologyDepartment of Infectious Diseases
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International Journal of Antimicrobial Agents
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