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Functionalized Deoxynucleotides and DNA Primers for Electrochemical Diagnostics of Disease Predispostions
UPMC Univ Paris 06, France.
Univ Rovira and Virgili, Spain.
Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering. Res Inst Sweden, Sweden.ORCID iD: 0000-0001-6889-0351
UPMC Univ Paris 06, France.
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2017 (English)In: SELECTED PROCEEDINGS FROM THE 231ST ECS MEETING, ELECTROCHEMICAL SOC INC , 2017, Vol. 77, no 11, p. 1873-1883Conference paper, Published paper (Refereed)
Abstract [en]

Redox labeled DNAs are of increasing interest for the fabrication of next generation molecular tools. In the present work we are investigating the use of various redox labeled dNTPs, ddNTPs and DNA primers for use in detection of diseases. We have reported the use of Polyoxometalate (POM) labeled DNA primers and dNTPs for use in PCR and subsequently used for direct electrochemical detection of PCR products. The use of POM labeled DNAs in PCR enabled us to check the compatibility with polymerases and PCR incorporability of the modified DNAs. Furthermore we have investigated the solid-phase array based primer extension (e-PEX) with redox labelled ddNTPs (ferrocene (Fc), anthraquinone (AQ) phenothiazine (PTZ) and methylene blue (MB)) to prove the strategy of detection of single nucleotide polymorphisms using the labeled ddNTPs. This strategy will allow the development of cost-effective, rapid and user-friendly platform for the screening of known and unknown genetic mutations.

Place, publisher, year, edition, pages
ELECTROCHEMICAL SOC INC , 2017. Vol. 77, no 11, p. 1873-1883
Series
ECS Transactions, ISSN 1938-5862
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:liu:diva-148402DOI: 10.1149/07711.1873ecstISI: 000432420500175ISBN: 978-1-62332-460-5 (electronic)ISBN: 978-1-60768-817-4 (print)OAI: oai:DiVA.org:liu-148402DiVA, id: diva2:1218546
Conference
Symposium on Plasma Nano Science and Technology held during the 231st Meeting of the Electrochemical-Society (ECS)
Note

Funding Agencies|European Unions Horizon research and innovation programme under the Marie Sklodowska-Curie grant [659211]; University Pierre and Marie Curie (UPMC), CNRS

Available from: 2018-06-14 Created: 2018-06-14 Last updated: 2018-06-14

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CiteExportLink to record
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