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Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals.
School of Medical Science, Inflammatory Response and Infection Susceptibility Centre, Uppsala University, Hospital of Västmanland Västerås.
Inflammatory Response and Infection Susceptibility Centre.
Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases. Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine.
School of Medical Sciences, Örebro University, Örebro, Sweden.
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2018 (English)In: Journal of bone and joint infection, ISSN 2206-3552, Vol. 3, no 1, p. 10-14Article in journal (Refereed) Published
Abstract [en]

Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.

Place, publisher, year, edition, pages
IvySpring , 2018. Vol. 3, no 1, p. 10-14
Keywords [en]
Staphylococcus epidermidis, caspase-1, neutrophils, prosthetic joint infections, host-pathogen interaction
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-148998DOI: 10.7150/jbji.21567PubMedID: 29545990OAI: oai:DiVA.org:liu-148998DiVA, id: diva2:1223155
Available from: 2018-06-25 Created: 2018-06-25 Last updated: 2019-04-12

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Nilsdotter-Augustinsson, Åsa
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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