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Normal tissue sparing potential of scanned proton beams with and without respiratory gating for the treatment of internal mammary nodes in breast cancer radiotherapy
The Skandion Clinic, Uppsala, Sweden.ORCID-id: 0000-0001-8171-2541
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Onkologiska kliniken US. The Skandion Clinic, Uppsala, Sweden.ORCID-id: 0000-0001-8425-8110
Medical Radiation Physics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
The Skandion Clinic, Uppsala, Sweden.ORCID-id: 0000-0002-7400-3234
2018 (engelsk)Inngår i: Physica medica (Testo stampato), ISSN 1120-1797, E-ISSN 1724-191X, Vol. 52, s. 81-85Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Proton therapy has shown potential for reducing doses to normal tissues in breast cancer radiotherapy. However data on the impact of protons when including internal mammary nodes (IMN) in the target for breast radiotherapy is comparatively scarce. This study aimed to evaluate normal tissue doses when including the IMN in regional RT with scanned proton beams, with and without respiratory gating. The study cohort was composed of ten left-sided breast patients CT-scanned during enhanced inspiration gating (EIG) and free-breathing (FB). Proton plans were designed for the target including or excluding the IMN. Targets and organs-at-risk were delineated according to RTOG guidelines. Comparison was performed between dosimetric parameters characterizing target coverage and OAR radiation burden. Statistical significance of differences was tested using a paired, two-tailed Student’s t-test. Inclusion of the IMN in the target volume led to a small increase of the cardiopulmonary burden. The largest differences were seen for the ipsilateral lung where the mean dose increased from 6.1 to 6.6 Gy (RBE) (P < 0.0001) in FB plans and from 6.9 to 7.4 Gy (RBE) (P = 0.003) in EIG plans. Target coverage parameters were very little affected by the inclusion of IMN into the treatment target. Radiotherapy with scanned proton beams has the potential of maintaining low cardiovascular burden when including the IMN into the target, irrespective of whether respiratory gating is used or not.

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Elsevier, 2018. Vol. 52, s. 81-85
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URN: urn:nbn:se:liu:diva-149606DOI: 10.1016/j.ejmp.2018.06.639ISI: 000442110000011PubMedID: 30139613OAI: oai:DiVA.org:liu-149606DiVA, id: diva2:1231896
Tilgjengelig fra: 2018-07-09 Laget: 2018-07-09 Sist oppdatert: 2018-09-03

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