liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Neural Mechanisms of Inflammation-Induced Fever
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-6928-4473
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences.
2018 (English)In: The Neuroscientist, ISSN 1073-8584, E-ISSN 1089-4098, Vol. 24, no 4, p. 381-399Article, review/survey (Refereed) Published
Abstract [en]

Fever is a common symptom of infectious and inflammatory disease. It is well-established that prostaglandin E-2 is the final mediator of fever, which by binding to its EP3 receptor subtype in the preoptic hypothalamus initiates thermogenesis. Here, we review the different hypotheses on how the presence of peripherally released pyrogenic substances can be signaled to the brain to elicit fever. We conclude that there is unequivocal evidence for a humoral signaling pathway by which proinflammatory cytokines, through their binding to receptors on brain endothelial cells, evoke fever by eliciting prostaglandin E-2 synthesis in these cells. The evidence for a role for other signaling routes for fever, such as signaling via circumventricular organs and peripheral nerves, as well as transfer into the brain of peripherally synthesized prostaglandin E-2 are yet far from conclusive. We also review the efferent limb of the pyrogenic pathways. We conclude that it is well established that prostaglandin E-2 binding in the preoptic hypothalamus produces fever by disinhibition of presympathetic neurons in the brain stem, but there is yet little understanding of the mechanisms by which factors such as nutritional status and ambient temperature shape the response to the peripheral immune challenge.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 24, no 4, p. 381-399
Keywords [en]
fever; cytokines; prostaglandin E2; brain endothelial cells; median preoptic nucleus; EP3 receptors
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-150242DOI: 10.1177/1073858418760481ISI: 000439623500009PubMedID: 29557255Scopus ID: 2-s2.0-85044398777OAI: oai:DiVA.org:liu-150242DiVA, id: diva2:1239819
Note

Funding Agencies|Swedish Medical Research Council [07879, 20725]; European Research Council; Knut and Alice Wallenberg foundation; Swedish Brain Foundation; Swedish Cancer Foundation [213/692]; County Council of Ostergotland

Available from: 2018-08-17 Created: 2018-08-17 Last updated: 2018-09-07Bibliographically approved

Open Access in DiVA

fulltext(1413 kB)62 downloads
File information
File name FULLTEXT01.pdfFile size 1413 kBChecksum SHA-512
635b10c6585be0124b97b0af11d7367384d07cacf8b32a13de1b04b098cad40030d49184324c1eaac63047d920838e5ba4d7547a20321f2a722688cd79a87a1c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records BETA

Blomqvist, Anders

Search in DiVA

By author/editor
Blomqvist, AndersEngblom, David
By organisation
Divison of NeurobiologyFaculty of Medicine and Health SciencesCenter for Social and Affective Neuroscience
In the same journal
The Neuroscientist
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 62 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 172 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf