liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Neural Mechanisms of Inflammation-Induced Fever
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.ORCID-id: 0000-0002-6928-4473
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten.
2018 (engelsk)Inngår i: The Neuroscientist, ISSN 1073-8584, E-ISSN 1089-4098, Vol. 24, nr 4, s. 381-399Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Fever is a common symptom of infectious and inflammatory disease. It is well-established that prostaglandin E-2 is the final mediator of fever, which by binding to its EP3 receptor subtype in the preoptic hypothalamus initiates thermogenesis. Here, we review the different hypotheses on how the presence of peripherally released pyrogenic substances can be signaled to the brain to elicit fever. We conclude that there is unequivocal evidence for a humoral signaling pathway by which proinflammatory cytokines, through their binding to receptors on brain endothelial cells, evoke fever by eliciting prostaglandin E-2 synthesis in these cells. The evidence for a role for other signaling routes for fever, such as signaling via circumventricular organs and peripheral nerves, as well as transfer into the brain of peripherally synthesized prostaglandin E-2 are yet far from conclusive. We also review the efferent limb of the pyrogenic pathways. We conclude that it is well established that prostaglandin E-2 binding in the preoptic hypothalamus produces fever by disinhibition of presympathetic neurons in the brain stem, but there is yet little understanding of the mechanisms by which factors such as nutritional status and ambient temperature shape the response to the peripheral immune challenge.

sted, utgiver, år, opplag, sider
Sage Publications, 2018. Vol. 24, nr 4, s. 381-399
Emneord [en]
fever; cytokines; prostaglandin E2; brain endothelial cells; median preoptic nucleus; EP3 receptors
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-150242DOI: 10.1177/1073858418760481ISI: 000439623500009PubMedID: 29557255Scopus ID: 2-s2.0-85044398777OAI: oai:DiVA.org:liu-150242DiVA, id: diva2:1239819
Merknad

Funding Agencies|Swedish Medical Research Council [07879, 20725]; European Research Council; Knut and Alice Wallenberg foundation; Swedish Brain Foundation; Swedish Cancer Foundation [213/692]; County Council of Ostergotland

Tilgjengelig fra: 2018-08-17 Laget: 2018-08-17 Sist oppdatert: 2018-09-07bibliografisk kontrollert

Open Access i DiVA

fulltext(1413 kB)70 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1413 kBChecksum SHA-512
635b10c6585be0124b97b0af11d7367384d07cacf8b32a13de1b04b098cad40030d49184324c1eaac63047d920838e5ba4d7547a20321f2a722688cd79a87a1c
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Blomqvist, Anders

Søk i DiVA

Av forfatter/redaktør
Blomqvist, AndersEngblom, David
Av organisasjonen
I samme tidsskrift
The Neuroscientist

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 70 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 196 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf