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Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain
Cty Hosp Ryhov, Sweden; Jonkoping Univ, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Acad Hlth and Care, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
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2018 (English)In: Cardiovascular Diabetology, ISSN 1475-2840, E-ISSN 1475-2840, Vol. 17, article id 113Article in journal (Refereed) Published
Abstract [en]

Aims: Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons. Methods: We prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies. The participants were grouped according to body mass index (normal weight amp;lt; 25 kg/m(2), overweight 25-29 kg/m(2), and obesity amp;gt;= 30 kg/m(2) ). Echocardiography was performed at the beginning of the study and after 4-years in the patient group. Results: Univariable and multivariable regression analysis revealed that variations in left ventricular ejection fraction, global longitudinal strain, left ventricular mass and diastolic function expressed as E/e (the ratio between early diastolic mitral flow and annular motion velocities) all are related to body mass index. The mean and standard deviation of left ventricular ejection fraction and global longitudinal strain values were 57% (8%) vs. - 18.6% (2.3%) for normal weight patients, 53% (8%) vs. - 17.5% (2.3%) for overweight, and 49% (9%) vs. - 16.2% (3.0%) for obese (p amp;lt; 0.05 vs. p amp;lt;0.05). Corresponding results in the control group were 58% (6%) vs. -22.3% (3.0%), 55% (7%) vs. - 20.8% (3.1%) and 54% (8%) - 19.6% (4.0%) (p amp;lt;0.05 vs. p amp;lt;0.05). Patients who gained weight from baseline to follow-up changed left ventricular ejection fraction (median and interquartile range) by - 1.0 (9.0) % (n =187) and patients who lost weight changed left ventricular ejection fraction by 1.0 (10.0) % (n =179) (p amp;lt;0.05). Conclusion: Overweight and obesity impair left ventricular ejection fraction and global longitudinal strain in both patients with type 2 diabetes mellitus and non-diabetic persons.

Place, publisher, year, edition, pages
BMC , 2018. Vol. 17, article id 113
Keywords [en]
Overweight; Obesity; Diabetes mellitus; Echocardiography
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-150862DOI: 10.1186/s12933-018-0756-2ISI: 000442121700001PubMedID: 30107798OAI: oai:DiVA.org:liu-150862DiVA, id: diva2:1245901
Note

Funding Agencies|FORSS; Research Council of Southeastern Sweden; Swedish Heart-Lung foundation; King Gustaf V and Queen Victoria Freemason Foundation, Sweden

Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2019-05-01

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Östgren, Carl Johan

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Sjöblom, PeterWijkman, MagnusEngvall, MartinLänne, TosteNyström, Fredrik HÖstgren, Carl JohanEngvall, Jan
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Division of Community MedicineFaculty of Medicine and Health SciencesDivision of Cardiovascular MedicineDepartment of Internal Medicine in NorrköpingDepartment of Medical and Health SciencesDepartment of Thoracic and Vascular SurgeryDepartment of EndocrinologyPrimary Health Care Center ÖdeshögDepartment of Clinical Physiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)
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