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Improved survival of Swedish glioblastoma patients treated according to Stupp
Cty Hosp Ryhov, Sweden.
Cty Hosp Ryhov, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Sinnescentrum, Neurokirurgiska kliniken US.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi.ORCID-id: 0000-0001-6716-0314
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2018 (engelsk)Inngår i: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 138, nr 4, s. 332-337Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

ObjectivesThe median survival in glioblastoma (GBM) patients used to be less than 1year. Surgical removal of the tumor with subsequent concomitant radiation/temozolomide (the Stupp regimen) has been shown to prolong survival. The Stupp protocol was implemented in the county of Jonkoping in 2006. The purpose of this study was to examine if the Stupp treatment has prolonged overall survival, in an unselected patient cohort with histologically verified GBM. Material and MethodThis study includes all patients from the county of Jonkoping, with a diagnosis of GBM from January 2001 to December 2012. Patients were divided into 2 cohorts, 2001-2005 and 2006-2012, that is before and after implementation of the Stupp regimen. By reviewing the medical case notes, the dates of the histological diagnosis and of death were identified. The median and mean overall survival and Kaplan-Meier survival analysis were calculated and compared between the 2 cohorts. ResultsThe mean survival was 110days longer in the cohort treated according to the Stupp regimen. Four patients in the 2006-2012 cohort and 1 patient in the 2001-2005 cohort are still alive. When comparing survival in patients with radical surgery vs biopsy, those that underwent radical surgery survived longer. The significance was slightly greater in the 2001-2005 cohort (mean 163 vs 344days, Pamp;lt;.001) than in the 2006-2012 cohort (mean 220 vs 397days, P=.02). ConclusionSurvival significantly improved after the implementation of the Stupp regimen in the study region of Sweden.

sted, utgiver, år, opplag, sider
WILEY , 2018. Vol. 138, nr 4, s. 332-337
Emneord [en]
glioblastoma; mortality; radiotherapy; Stupp treatment; survival; temozolomide
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-151465DOI: 10.1111/ane.12966ISI: 000443931400010PubMedID: 29882211OAI: oai:DiVA.org:liu-151465DiVA, id: diva2:1250682
Merknad

Funding Agencies|Gustav Lindholms Stiftelse for elakartade hjarntumorer; Futurum

Tilgjengelig fra: 2018-09-24 Laget: 2018-09-24 Sist oppdatert: 2019-10-14

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