liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Positively-charged hierarchical PEDOT interface with enhanced electrode kinetics for NADH-based biosensors
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-1815-9699
Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0003-3274-6029
2018 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 120, p. 115-121Article in journal (Refereed) Published
Abstract [en]

Poly(ethylenedioxythiophene) (PEDOT) has attracted considerable attention as an advanced electrode material for electrochemical sensors and biosensors, due to its unique electrical and physicochemical properties. Here, we demonstrate the facile preparation of a positively-charged and hierarchical micro-structured PEDOT electrochemical interface with enhanced electrode kinetics for the electrooxidation of NADH. Processable PEDOT colloidal microparticles (PEDOT CMs) were synthesised by template-assisted polymerisation and were then utilised as building blocks for the fabrication of hierarchically-structured electrodes with a larger accessible electroactive surface (2.8 times larger than that of the benchmark PEDOT:PSS) and inter-particle space, thus improving electrode kinetics. The intrinsic positive charge of the PEDOT CMs further facilitated the detection of negatively-charged molecules by electrostatic accumulation. Due to the synergistic effect, these hierarchically-structured PEDOT CMs electrodes exhibited improved NADH electrooxidation at lower potentials and enhanced electrocatalytic activity compared to the compact structure of conventional PEDOT:PSS electrodes. The PEDOT CMs electrodes detected NADH over the range of 20–240 μM, with a sensitivity of 0.0156 μA/μM and a limit of detection of 5.3 μM. Moreover, the PEDOT CMs electrode exhibited a larger peak separation from the interferent ascorbic acid, and improved stability. This enhanced analytical performance for NADH provides a sound basis for further work coupling to a range of NAD-dependent dehydrogenases for applications in biosensing, bio-fuel cells and biocatalysis.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 120, p. 115-121
Keywords [en]
Processable, PEDOT, Hierarchical structure, Surface charge, NADH sensing
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-151892DOI: 10.1016/j.bios.2018.08.017ISI: 000446288900016PubMedID: 30173009Scopus ID: 2-s2.0-85052522458OAI: oai:DiVA.org:liu-151892DiVA, id: diva2:1254383
Note

Funding agencies: Swedish Research Council [VR-2015-04434, VR-2014-43058]; China Scholarship Council [201606910036]

Available from: 2018-10-09 Created: 2018-10-09 Last updated: 2018-10-17Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Turner, AnthonyMak, Wing Cheung

Search in DiVA

By author/editor
Meng, LingyinTurner, AnthonyMak, Wing Cheung
By organisation
Sensor and Actuator SystemsFaculty of Science & Engineering
In the same journal
Biosensors & bioelectronics
Physical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 82 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf