liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
Univ Malaya, Malaysia.
Univ Malaya, Malaysia.
Xiamen Univ Malaysia, Malaysia.
CUTN, India.
Show others and affiliations
2018 (English)In: CELLS, ISSN 2073-4409, Vol. 7, no 10, article id 165Article, review/survey (Refereed) Published
Abstract [en]

Hepatitis C virus (HCV) represents a challenging global health threat to similar to 200 million infected individuals. Clinical data suggest that only similar to 10-15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-specific immune responses, which is largely attributed to difficulties in recognizing the pathognomonic symptoms during the initial stages of exposure to the virus. Given the paucity of a suitable small animal model, it is also equally challenging to study the early phases of viral establishment. Further, the host factors contributing to HCV chronicity in a vast majority of acutely HCV-infected individuals largely remain unexplored. The last few years have witnessed a surge in studies showing that HCV adopts myriad mechanisms to disconcert virus-specific immune responses in the host to establish persistence, which includes, but is not limited to viral escape mutations, viral growth at privileged sites, and antagonism. Here we discuss a few hitherto poorly explained mechanisms employed by HCV that are believed to lead to chronicity in infected individuals. A better understanding of these mechanisms would aid the design of improved therapeutic targets against viral establishment in susceptible individuals.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 7, no 10, article id 165
Keywords [en]
apoptosis; viral persistence; hepatitis C virus; immunity; chronic infection
National Category
Other Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-152826DOI: 10.3390/cells7100165ISI: 000448818800023PubMedID: 30322028OAI: oai:DiVA.org:liu-152826DiVA, id: diva2:1265230
Note

Funding Agencies|High Impact Research (HIR), University of Malaya [625/1/HIR/139]; University Malaya Fellowship Scheme [FG019-17AFR]; Swedish Research Council [AI52731]; Swedish Physicians Against AIDS Research Foundation; Swedish International Development Cooperation Agency; SIDA SARC; VINNMER for Vinnova; Linkoping University Hospital Research Fund; CALF; Swedish Society of Medicine (SvenskaLakaresallskapet)

Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2019-03-07

Open Access in DiVA

fulltext(248 kB)87 downloads
File information
File name FULLTEXT01.pdfFile size 248 kBChecksum SHA-512
c5d4f061e983e0d1dcde9a93a39c03deb1d918a2d5768168dc033ad592d815427a9c4b1455258d4972556e20c077f104f0b64697ad85fdc57d76cbecfc914097
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Larsson, Marie
By organisation
Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
Other Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 87 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 303 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf