liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
Univ Malaya, Malaysia.
Univ Malaya, Malaysia.
Xiamen Univ Malaysia, Malaysia.
CUTN, India.
Vise andre og tillknytning
2018 (engelsk)Inngår i: CELLS, ISSN 2073-4409, Vol. 7, nr 10, artikkel-id 165Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Hepatitis C virus (HCV) represents a challenging global health threat to similar to 200 million infected individuals. Clinical data suggest that only similar to 10-15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-specific immune responses, which is largely attributed to difficulties in recognizing the pathognomonic symptoms during the initial stages of exposure to the virus. Given the paucity of a suitable small animal model, it is also equally challenging to study the early phases of viral establishment. Further, the host factors contributing to HCV chronicity in a vast majority of acutely HCV-infected individuals largely remain unexplored. The last few years have witnessed a surge in studies showing that HCV adopts myriad mechanisms to disconcert virus-specific immune responses in the host to establish persistence, which includes, but is not limited to viral escape mutations, viral growth at privileged sites, and antagonism. Here we discuss a few hitherto poorly explained mechanisms employed by HCV that are believed to lead to chronicity in infected individuals. A better understanding of these mechanisms would aid the design of improved therapeutic targets against viral establishment in susceptible individuals.

sted, utgiver, år, opplag, sider
MDPI , 2018. Vol. 7, nr 10, artikkel-id 165
Emneord [en]
apoptosis; viral persistence; hepatitis C virus; immunity; chronic infection
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-152826DOI: 10.3390/cells7100165ISI: 000448818800023PubMedID: 30322028OAI: oai:DiVA.org:liu-152826DiVA, id: diva2:1265230
Merknad

Funding Agencies|High Impact Research (HIR), University of Malaya [625/1/HIR/139]; University Malaya Fellowship Scheme [FG019-17AFR]; Swedish Research Council [AI52731]; Swedish Physicians Against AIDS Research Foundation; Swedish International Development Cooperation Agency; SIDA SARC; VINNMER for Vinnova; Linkoping University Hospital Research Fund; CALF; Swedish Society of Medicine (SvenskaLakaresallskapet)

Tilgjengelig fra: 2018-11-22 Laget: 2018-11-22 Sist oppdatert: 2019-03-07

Open Access i DiVA

fulltext(248 kB)73 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 248 kBChecksum SHA-512
c5d4f061e983e0d1dcde9a93a39c03deb1d918a2d5768168dc033ad592d815427a9c4b1455258d4972556e20c077f104f0b64697ad85fdc57d76cbecfc914097
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Larsson, Marie
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 73 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 294 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf