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Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
Univ Malaya, Malaysia.
Univ Malaya, Malaysia.
Xiamen Univ Malaysia, Malaysia.
CUTN, India.
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2018 (Engelska)Ingår i: CELLS, ISSN 2073-4409, Vol. 7, nr 10, artikel-id 165Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Hepatitis C virus (HCV) represents a challenging global health threat to similar to 200 million infected individuals. Clinical data suggest that only similar to 10-15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-specific immune responses, which is largely attributed to difficulties in recognizing the pathognomonic symptoms during the initial stages of exposure to the virus. Given the paucity of a suitable small animal model, it is also equally challenging to study the early phases of viral establishment. Further, the host factors contributing to HCV chronicity in a vast majority of acutely HCV-infected individuals largely remain unexplored. The last few years have witnessed a surge in studies showing that HCV adopts myriad mechanisms to disconcert virus-specific immune responses in the host to establish persistence, which includes, but is not limited to viral escape mutations, viral growth at privileged sites, and antagonism. Here we discuss a few hitherto poorly explained mechanisms employed by HCV that are believed to lead to chronicity in infected individuals. A better understanding of these mechanisms would aid the design of improved therapeutic targets against viral establishment in susceptible individuals.

Ort, förlag, år, upplaga, sidor
MDPI , 2018. Vol. 7, nr 10, artikel-id 165
Nyckelord [en]
apoptosis; viral persistence; hepatitis C virus; immunity; chronic infection
Nationell ämneskategori
Annan klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-152826DOI: 10.3390/cells7100165ISI: 000448818800023PubMedID: 30322028OAI: oai:DiVA.org:liu-152826DiVA, id: diva2:1265230
Anmärkning

Funding Agencies|High Impact Research (HIR), University of Malaya [625/1/HIR/139]; University Malaya Fellowship Scheme [FG019-17AFR]; Swedish Research Council [AI52731]; Swedish Physicians Against AIDS Research Foundation; Swedish International Development Cooperation Agency; SIDA SARC; VINNMER for Vinnova; Linkoping University Hospital Research Fund; CALF; Swedish Society of Medicine (SvenskaLakaresallskapet)

Tillgänglig från: 2018-11-22 Skapad: 2018-11-22 Senast uppdaterad: 2019-03-07

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